5-HT Receptors

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  • Anpirtoline hydrochloride

    Anpirtoline hydrochloride is a highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively), which decreases central serotonin synthesis and attenuates aggressive behavior in vivo. It also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant. Learn More

    Starting at: $119.00

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  • LY 393558

    LY 393558 is a dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Learn More

    Starting at: $139.00

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  • 5-Nonyloxytryptamine oxalate

    GR 159897 is a potent, selective, non-peptide, orally active neurokinin NK2 receptor antagonist , which inhibits NK2 receptor-mediated contraction of guinea pig trachea with a pA2 of 8.7. Learn More

    Starting at: $105.00

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  • SB 206553 hydrochloride

    L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors. Learn More

    Starting at: $145.00

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  • PNU 22394 hydrochloride

    MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn More

    Starting at: $95.00

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  • Ro 60-0175 fumarate

    Dibutyryl-cAMP, sodium salt is a cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Learn More

    Starting at: $105.00

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  • SB 216641 hydrochloride

    CD 2665 is a selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Learn More

    Starting at: $145.00

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  • Isamoltane hemifumarate

    Isamoltane hemifumarate is a 5-HT1B antagonist, approximately 30-fold selective over 5-HT1A. Learn More

    Starting at: $89.00

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  • WAY 629 hydrochloride

    WAY 629 hydrochloride is a selective 5-HT2C agonist with Ki values of 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Learn More

    Starting at: $109.00

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  • MK 212 hydrochloride

    MK 212 hydrochloride is a 5-HT receptor agonist with selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively). Learn More

    Starting at: $92.00

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  • WAY 161503 hydrochloride

    WAY 161503 hydrochloride is a potent and selective 5-HT2C receptor agonist with antidepressant effect following systemic administration in vivo. Learn More

    Starting at: $99.00

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  • Eltoprazine hydrochloride

    Eltoprazine hydrochloride is a 5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively), which reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. Learn More

    Starting at: $99.00

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  • Org 12962 hydrochloride

    Org 12962 hydrochloride is a selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively), which displays antiaversive effects in a rat model of panic-like anxiety. Learn More

    Starting at: $105.00

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  • NAS-181

    NAS-181 is a potent, selective antagonist at the rat 5-HT1B receptor (Ki = 47 nM). Learn More

    Starting at: $155.00

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  • SB 243213 dihydrochloride

    SB 243213 dihydrochloride is a selective 5-HT2C inverse agonist (pKb = 9.8), which displays selectivity over other 5-HT2 subtypes (pKi values are 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C respectively). Learn More

    Starting at: $140.00

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  • CGS 12066B dimaleate

    CGS 12066B dimaleate is a 5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Learn More

    Starting at: $60.00

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  • CP 93129 dihydrochloride

    CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist. Learn More

    Starting at: $105.00

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  • CP 94253 hydrochloride

    CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Learn More

    Starting at: $140.00

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  • SB 200646 hydrochloride

    SB 200646 hydrochloride is a 5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Learn More

    Starting at: $135.00

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  • 1-Methylpsilocin

    1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively) which displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Learn More

    Starting at: $95.00

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