5-HT Receptors

NPS ALX Compound 4a dihydrochloride

NPS ALX Compound 4a dihydrochloride is a potent and competitive 5-HT6 antagonist (IC50 = 7.2 nM, Ki = 0.2 nM) that displays selectivity over other 5-HT and D2 receptors. Learn More

Starting at: $139.00

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SGS 518 oxalate

SGS 518 oxalate is a selective antagonist of the 5-HT6 subtype of the serotonin receptor. Learn More

Starting at: $139.00

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EMD 386088 hydrochloride

EMD 386088 hydrochloride is a potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Learn More

Starting at: $99.00

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WAY 208466 dihydrochloride

WAY 208466 dihydrochloride is a high affinity, selective 5-HT6 agonist with antidepressant and anxiolytic-like effects. Learn More

Starting at: $149.00

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LY 334370 hydrochloride

LY 334370 hydrochloride is a selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Learn More

Starting at: $140.00

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LY 344864 hydrochloride

LY 344864 hydrochloride is a potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Learn More

Starting at: $130.00

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SB 699551

SB 699551 is a selective 5-ht5a receptor antagonist. Learn More

Starting at: $145.00

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BRL 54443

BRL 54443 acts as a selective agonist for the 5-HT1E and 5-HT1F serotonin receptor subtypes with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors. Learn More

Starting at: $92.00

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L-694,247

L-694,247 is a selective and extremely potent 5-HT1D receptor agonist. Learn More

Starting at: $135.00

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SDZ SER 082 fumarate

SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors which inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8, and Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34). Learn More

Starting at: $135.00

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L-703,664 succinate

L-703,664 succinate is a 5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors). Learn More

Starting at: $140.00

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GR 127935 hydrochloride

GR 127935 hydrochloride is a potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors) which displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Learn More

Starting at: $155.00

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CP 135807

CP 135807 is a selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration. Learn More

Starting at: $135.00

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SB 204741

SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95) which displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors. Learn More

Starting at: $115.00

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LY 272015 hydrochloride

LY 272015 hydrochloride is a high affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Learn More

Starting at: $135.00

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LY 266097 hydrochloride

LY 266097 hydrochloride is a selective 5-HT2B receptor antagonist (pKi = 9.3). Learn More

Starting at: $135.00

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m-CPP hydrochloride

m-CPP hydrochloride is a 5-HT2C/2B receptor agonist/partial agonist with pEC50 values of 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Learn More

Starting at: $38.00

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BW 723C86 hydrochloride

DMP 543 is a K+ channel blocker and acetylcholine release stimulator, which potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Learn More

Starting at: $95.00

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α-Methyl-5-hydroxytryptamine maleate

α-Methyl-5-hydroxytryptamine maleate is a 5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively. Learn More

Starting at: $75.00

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PNU 142633

PNU 142633 is a very selective, high affinity 5-HT1D receptor agonist (Ki values are 6 and > 18000 nM at human 5-HT1D and 5-HT1B receptors respectively), which inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo. Learn More

Starting at: $149.00

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