5-HT Receptors
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RS 39604 hydrochloride
Potent cholinesterase inhibitor, a cognition enhancer in vivo. Learn MoreStarting at: $110.00
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Tegaserod maleate
Tegaserod maleate is a partial agonist of 5-HT4 (Ki = 12 nM). Learn MoreStarting at: $119.00
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RS 23597-190 hydrochloride
RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT4 receptors. Learn MoreStarting at: $90.00
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ML 10302 hydrochloride
ML 10302 hydrochloride is a potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo. Learn MoreStarting at: $80.00
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SB 204070
SB 204070 is a potent and selective 5-HT4 receptor antagonist (pIC50 = 10.1). Displays >5000-fold selectivity for 5-HT4 over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, and 5-HT3 receptors which exhibits anxiolytic activity upon systemic administration in vivo. Learn MoreStarting at: $140.00
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GR 125487 sulfamate
GR 125487 sulfamate is a potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Learn MoreStarting at: $135.00
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GR 113808
GR 113808 is a potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors) which displays > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. Learn MoreStarting at: $115.00
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SB 203186 hydrochloride
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors. Learn MoreStarting at: $95.00
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BIMU 8
BIMU 8 is a potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors), which binds to receptors in a mechanism different to that of the endogenous ligand 5-HT. Learn MoreStarting at: $125.00
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GR 46611
GR 46611 is a 5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands. Learn MoreStarting at: $120.00
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PNU 109291
PNU 109291 is a potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Learn MoreStarting at: $155.00
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PNU 142633
PNU 142633 is a very selective, high affinity 5-HT1D receptor agonist (Ki values are 6 and > 18000 nM at human 5-HT1D and 5-HT1B receptors respectively), which inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo. Learn MoreStarting at: $149.00
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α-Methyl-5-hydroxytryptamine maleate
α-Methyl-5-hydroxytryptamine maleate is a 5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively. Learn MoreStarting at: $75.00
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BW 723C86 hydrochloride
DMP 543 is a K+ channel blocker and acetylcholine release stimulator, which potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Learn MoreStarting at: $95.00
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m-CPP hydrochloride
m-CPP hydrochloride is a 5-HT2C/2B receptor agonist/partial agonist with pEC50 values of 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Learn MoreStarting at: $38.00
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LY 266097 hydrochloride
LY 266097 hydrochloride is a selective 5-HT2B receptor antagonist (pKi = 9.3). Learn MoreStarting at: $135.00
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LY 272015 hydrochloride
LY 272015 hydrochloride is a high affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Learn MoreStarting at: $135.00
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SB 204741
SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95) which displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors. Learn MoreStarting at: $115.00
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CP 135807
CP 135807 is a selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration. Learn MoreStarting at: $135.00
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GR 127935 hydrochloride
GR 127935 hydrochloride is a potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors) which displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Learn MoreStarting at: $155.00