Retinoic Acid Receptors

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  • EC 23

    EC 23 is Photostable synthetic retinoid and displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Learn More

    Starting at: $135.00

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  • AC 55649

    AC 55649 is a potent, isoform-selective RARβ2 receptor agonist that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. Learn More

    Starting at: $99.00

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  • CD 2665

    SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively) which displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. Learn More

    Starting at: $140.00

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  • BMS 453

    R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist which displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM) and inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. Learn More

    Starting at: $135.00

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  • MM 11253

    MM 11253 is a selective RARγ antagonist, which blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Learn More

    Starting at: $139.00

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  • BMS 195614

    BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM) which displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Learn More

    Starting at: $159.00

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  • BMS 753

    BMS 753 is a RARα-selective agonist (Ki = 2 nM). Learn More

    Starting at: $120.00

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  • BMS 493

    BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist, which enhances nuclear corepressor (NCoR) interaction with RARs. Learn More

    Starting at: $135.00

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  • ER 50891

    ER 50891 is a antagonist of RARα receptors (IC50 = 31.2 nM), which displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively). Learn More

    Starting at: $155.00

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  • BMS 961

    BMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Learn More

    Starting at: $135.00

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  • LE 135

    LE 135 is a retinoic acid antagonist; displays moderate selectivity for RARβ over RARα Learn More

    Starting at: $105.00

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  • Ch 55

    Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP) and Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Learn More

    Starting at: $90.00

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  • CD 1530

    CD 1530 is a potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM). Learn More

    Starting at: $95.00

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  • AC 261066

    AC 261066 is a potent RARβ2 agonist with a pEC50 value of 8.1. Learn More

    Starting at: $139.00

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