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Peptide Receptors
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SB 222200
SB 222200 is a potent and selective non-peptide NK3 receptor antagonist. Ki values are 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors respectively. Learn MoreStarting at: $90.00
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SB 223412
SB 223412 is a potent and selective non-peptide NK3 receptor antagonist (Ki values are 1, 144 and >100000 nM for human NK3, NK2 and NK1 receptors respectively). Learn MoreStarting at: $120.00
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SSR 146977 hydrochloride
SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively), which also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM). Learn MoreStarting at: $169.00
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FR 139317
FR 139317 is a highly potent and selective ETA endothelin receptor antagonist (Ki values are 1 nM and 7.3 μM at ETA and ETB subtypes respectively). Learn MoreStarting at: $155.00
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ZD 7155 hydrochloride
ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Learn MoreStarting at: $115.00
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L-732,138
L-732,138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM). Learn MoreStarting at: $65.00
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L-733,060 hydrochloride
L-733,060 hydrochloride is a potent antagonist of human tachykinin NK1 receptors (Ki values are 0.08, 0.2 and 93.13 nM for gerbil, human and rat receptors respectively) which produces anxiolytic-like effects in the gerbil elevated plus-maze. Learn MoreStarting at: $140.00
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FK 888
FK 888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors which inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration. Learn MoreStarting at: $195.00
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CP 99994 dihydrochloride
CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro) which displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Learn MoreStarting at: $150.00
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SR 27897
SR 27897 is a potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Learn MoreStarting at: $135.00
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RP 67580
RP 67580 is a potent and selective tachykinin NK1 receptor antagonist (Ki values are 2.9 nM and > 10 μM for rat NK1, and rat NK2 and NK3 receptors respectively), which displays higher affinity at rat and mouse than human receptors. Learn MoreStarting at: $135.00
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CP 96345
CP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Learn MoreStarting at: $135.00
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Devazepide
Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Devazepide blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration. Learn MoreStarting at: $149.00
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BMS 182874 hydrochloride
BMS 182874 hydrochloride is a potent, selective and competitive non-peptide endothelin ETA receptor antagonist (Ki = 48 nM) which displays > 1000-fold selectivity over ETB receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo and inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro. Learn MoreStarting at: $140.00
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SR 140333
SR 140333 is a potent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM) which inhibits substance P-invoked calcium mobilization and outward current (IC50 = 1.3 nM) and blocks NK1-mediated nitric oxide-dependent vasodilation in vivo. Learn MoreStarting at: $180.00
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CI 1020
Flunitrazepam is a ligand at the GABAA receptor benzodiazepine modulatory site which exhibits hypnotic effects and also displays anxiolytic and sedative properties. Learn MoreStarting at: $65.00
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Antalarmin hydrochloride
Antalarmin hydrochloride is a non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM), which suppresses CRF-induced ACTH secretion and blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety. Learn MoreStarting at: $140.00
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SN 003
SN 003 is a reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Learn MoreStarting at: $140.00
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L-168,049
L-168,049 is a very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Learn MoreStarting at: $105.00
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L 760735
L 760735 is a high affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors), which is selective (>300-fold) over h-NK2 and h-NK3 receptors and exhibits anxiolytic and antidepressant-like effects. Learn MoreStarting at: $145.00
