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Peptide Receptors
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WAY 207024 dihydrochloride
WAY 207024 dihydrochloride is a gonadotropin releasing hormone receptor (GnRH-R) antagonist that exhibits potent affinity with IC50 values of 12 and 71 nM for human and rat GnRH receptors respectively. Learn MoreStarting at: $189.00
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AG 045572
AG 045572 is a selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Learn MoreStarting at: $79.00
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T 98475
T 98475 is a potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 values are 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors respectively) which inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys. Learn MoreStarting at: $145.00
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Tabimorelin hemifumarate
Tabimorelin hemifumarate is a potent, orally active ghrelin receptor (GHS-R1a) agonist (Ki = 50 nM at human recombinant GHS-R1a), which induces hyperphagia and adiposity in lean rats, but not in leptin signaling-deficient ZDF rats. Learn MoreStarting at: $229.00
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L-692,585
L-692,585 is a highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (Ki = 0.8 nM) which increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6. Learn MoreStarting at: $185.00
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FPR A14
FPR A14 is a formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Learn MoreStarting at: $119.00
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SUN-B 8155
SUN-B 8155 is a non-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC50 = 21 μM). Learn MoreStarting at: $109.00
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SB 268262
SB 268262 is a selective non-peptide CGRP1 antagonist which inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively). Learn MoreStarting at: $155.00
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WIN 64338 hydrochloride
L-NIL hydrochloride is the first potent, non-peptide, competitive bradykinin B2 receptor antagonist. Learn MoreStarting at: $110.00
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PD 176252
PD 176252 is a non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively), which inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Learn MoreStarting at: $189.00
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TCS OX2 29
TCS OX2 29 is a potent orexin 2 receptor (OX2) antagonist (IC50 = 40 nM) that displays > 250 fold selectivity over OX1 and over 50 other receptors, ion channels and transporters. Learn MoreStarting at: $139.00
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GR 159897
SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92) which displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). Learn MoreStarting at: $140.00
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ML 221
ML 221 is an apelin receptor (APJ) antagonist with IC50 values of 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Learn MoreStarting at: $139.00
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L-365,260
L-365,260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors. Learn MoreStarting at: $135.00
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PD 135158
PD 135158 is a potent and selective, nonpeptide CCK2 receptor antagonist (IC50 values are 2.8 and 1232 nM for CCK2 and CCK1 respectively) that displays negligible affinity at GABAA, benzodiazepine, substance P, neurotensin, opioid, bradykinin and 5-HT3 receptors (IC50 > 10 μM). Learn MoreStarting at: $175.00
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CI 988
CI 988 is a potent and selective CCK2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors (IC50 values are 1.7 and 2717 nM for CCK2 and CCK1 respectively). Learn MoreStarting at: $175.00
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LY 225910
LY 225910 is a potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes). Learn MoreStarting at: $105.00
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YM 022
YM 022 is an extremely potent and highly selective non-peptide CCK2 silent antagonist (Ki values are 68 pM and 63 nM at CCK2 and CCK1 receptors respectively). Learn MoreStarting at: $135.00
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LY 288513
LY 288513 is a selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively) which displays anxiolytic and antipsychotic properties in vivo. Learn MoreStarting at: $195.00
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SB 218795
SB 218795 is a potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3) which displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Learn MoreStarting at: $140.00
