Ligand-gated Ion Channels
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SR 16584
SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM), which selectively binds α3β4 over α4β2 and α7 subtypes (Ki values are 0.508, >100 and >100 μM, respectively). Learn MoreStarting at: $125.00
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UB 165 fumarate
UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively. Learn MoreStarting at: $179.00
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CX 546
CX 546 is an AMPA receptor potentiator, which binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Learn MoreStarting at: $90.00
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IDRA 21
IDRA 21 is an inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. Learn MoreStarting at: $119.00
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Cl-HIBO
Cl-HIBO is a subtype-selective and strongly desensitising AMPA receptor agonist. Learn MoreStarting at: $179.00
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(R)-AMPA
(R)-AMPA is an inactive enantiomer of AMPA. Learn MoreStarting at: $229.00
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(S)-AMPA
(S)-AMPA is an active enantiomer of AMPA with an EC50 value of 3.5 μM. Learn MoreStarting at: $79.00
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(RS)-AMPA hydrobromide
(RS)-AMPA hydrobromide is a more water soluble hydrobromide salt of (RS)-AMPA. Learn MoreStarting at: $79.00
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Piracetam
Piracetam is a nootropic that displays cognitive enhancing properties.It facilitates efficiency of cholinergic neurotransmission at muscarinic receptors. Learn MoreStarting at: $55.00
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(RS)-AMPA
(RS)-AMPA is a prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors. Learn MoreStarting at: $139.00
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UBP 282
UBP 282 is an AMPA and kainate receptor antagonist. Learn MoreStarting at: $139.00
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L-Quisqualic acid
L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Learn MoreStarting at: $65.00
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Talampanel
L-371,257 is a potent, high affinity human oxytocin (OT) receptor antagonist (Ki = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V1a and V2. Learn MoreStarting at: $125.00
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ZK 200775
Benzamil is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Learn MoreStarting at: $140.00
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IEM 1925 dihydrobromide
IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Learn MoreStarting at: $109.00
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Dihydro-β-erythroidine hydrobromide
Dihydro-β-erythroidine hydrobromide is a competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors respectively). Learn MoreStarting at: $129.00
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1-BCP
1-BCP is a centrally active selective potentiator of AMPA-mediated responses. Learn MoreStarting at: $95.00
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Diazoxide
Diazoxide is an antihypertensive, activates ATP-dependent K+ channels (Kir6), which induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Learn MoreStarting at: $55.00
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CMPDA
CMPDA is a positive allosteric modulator of GluR2 receptors (EC50 values are 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay), which binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges. Learn MoreStarting at: $129.00
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(S)-CPW 399
(S)-CPW 399 is a novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (Ki values are 44, 109, 223, 1890 and 2090 nM at GluR5, GluR1, GluR2, GluR3 and GluR4 receptors respectively). Learn MoreStarting at: $139.00