Page 4 | Ligand-gated Ion Channels

AZ 10606120 dihydrochloride

AZ 10606120 dihydrochloride is a potent P2X7 receptor antagonist that binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Learn More

Starting at: $121.00

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2-Methylthioadenosine triphosphate tetrasodium salt

2-Methylthioadenosine triphosphate tetrasodium salt is a P2 purinoceptor agonist. Learn More

Starting at: $179.00

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NF 449

NF 449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Learn More

Starting at: $139.00

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AZ 11645373

AZ 11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Learn More

Starting at: $140.00

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GYKI 53655 hydrochloride

GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist, which blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. Learn More

Starting at: $135.00

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YM 90K hydrochloride

YM 90K hydrochloride is a selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. Learn More

Starting at: $150.00

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SYM 2206

SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50 = 2.8 μM ). Learn More

Starting at: $125.00

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S 18986

S 18986 is a positive allosteric modulator of AMPA receptors which exhibits cognitive enhancing properties in rodent behavioral models. Learn More

Starting at: $135.00

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CFM-2

CFM-2 is a novel, selective non-competitive AMPA antagonist. Learn More

Starting at: $135.00

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SIB 1553A hydrochloride

SIB 1553A hydrochloride is a nicotinic acetylcholine receptor (nAChR) agonist which displays selectivity for β4 subunit-containing receptors. Learn More

Starting at: $105.00

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CP 465022 hydrochloride

CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity, which also significantly blocks the persistent component of Nav1.6 channel activity. Learn More

Starting at: $110.00

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PEPA

PEPA is a novel allosteric potentiator of AMPA receptor desensitization. Learn More

Starting at: $105.00

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(S)-(-)-5-Fluorowillardiine

(S)-(-)-5-Fluorowillardiine is a more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). Learn More

Starting at: $140.00

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NPEC-caged-(S)-AMPA

NPEC-caged-(S)-AMPA is a 1-(2-nitrophenyl)ethyl caged version of (S)-AMPA. Learn More

Starting at: $215.00

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Naspm trihydrochloride

Naspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors, which blocks AMPA receptors lacking the GluR2 subunit, and protects hippocampal neurons against global ischemia-induced cell death. Learn More

Starting at: $140.00

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GYKI 47261 dihydrochloride

GYKI 47261 dihydrochloride is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM), which displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo. Learn More

Starting at: $135.00

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IEM 1460

IEM 1460 is a voltage-dependent open-channel blocker of AMPA receptors which displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors (IC50 values are 2.6 and 1102 μM respectively). Learn More

Starting at: $85.00

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