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Ligand-gated Ion Channels
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Ifenprodil hemitartrate
Ifenprodil hemitartrate is a NMDA receptor antagonist, acting at the polyamine site. Learn MoreStarting at: $65.00
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(RS)-CPP
(RS)-CPP is a potent NMDA antagonist. Separate isomer (R)-CPP also available. Learn MoreStarting at: $129.00
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MNI-caged-NMDA
MNI-caged-NMDA is a NMDA caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Learn MoreStarting at: $175.00
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QNZ 46
QNZ 46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Learn MoreStarting at: $130.00
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(R)-(+)-HA-966
(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor. Learn MoreStarting at: $95.00
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LY 233053
LY 233053 is a competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM, and nhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats. Learn MoreStarting at: $65.00
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(R)-CPP
(R)-CPP is a highly potent NMDA antagonist, which shows some selectivity for NR2A-containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 μM for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively). Learn MoreStarting at: $245.00
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CGP 37849
CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Learn MoreStarting at: $115.00
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CGP 39551
CGP 39551 is a potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Learn MoreStarting at: $115.00
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N-(4-Hydroxyphenylacetyl)spermine
N-(4-Hydroxyphenylacetyl)spermine is a wasp toxin analog, which has been reported to be selective for NMDA receptors in mammalian CNS. Learn MoreStarting at: $125.00
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Eliprodil
Eliprodil is a non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Learn MoreStarting at: $90.00
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5,7-Dichlorokynurenic acid sodium salt
Sodium salt of 5,7-Dichlorokynurenic acid, a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). Learn MoreStarting at: $65.00
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CGS 19755
CGS 19755 is a potent, competitive NMDA receptor antagonist. Learn MoreStarting at: $129.00
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L-Cysteinesulfinic acid
L-Cysteinesulfinic acid is a agonist at mGlu1a and mGlu5a subtypes expressed in clonal RGT cell lines. Also agonist at NMDA and PLD-coupled mGlu receptors. Learn MoreStarting at: $70.00
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Remacemide hydrochloride
Remacemide hydrochloride is a non-competitive NMDA receptor antagonist which blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Learn MoreStarting at: $115.00
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(S)-(-)-HA-966
(S)-(-)-HA-966 is a possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. Learn MoreStarting at: $95.00
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HU 211
HU 211 is a NMDA antagonist (IC50 = 11 μM for inhibition of [3H]MK-801 binding to rat forebrain membranes), which exhibits beneficial effects in experimental models of multiple sclerosis, bacterial meningitis, septic shock, epilepsy, and traumatic and ischemic brain injury. Brain penetrant. Learn MoreStarting at: $270.00
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PPPA
PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively). Learn MoreStarting at: $130.00
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PMPA (NMDA antagonist)
PMPA (NMDA antagonist) is a competitive NMDA receptor antagonist, which displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at NR2A, NR2B, NR2C and NR2D subunit-containing receptors respectively. Learn MoreStarting at: $125.00
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D-CPP-ene
D-CPP-ene is a potent and competitive NMDA antagonist (Ki = 40 nM). Learn MoreStarting at: $270.00
