Ligand-gated Ion Channels
-
Phencyclidine hydrochloride
Phencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Learn MoreStarting at: $55.00
-
DQP 1105
DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM respectively). Learn MoreStarting at: $119.00
-
cis-ACPD
cis-ACPD is a 1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo. Learn MoreStarting at: $125.00
-
PHA 543613 hydrochloride
PHA 543613 hydrochloride is a potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors, which positively influences sensory gating and memory in in vivo models of schizophrenia. Learn MoreStarting at: $149.00
-
CIQ
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit, which increases channel opening efficiency and enhances NMDA receptor responses. Learn MoreStarting at: $119.00
-
Homoquinolinic acid
Homoquinolinic acid is a potent NMDA receptor agonist; subtype-selective. Learn MoreStarting at: $129.00
-
NS 1738
NS 1738 is a selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Learn MoreStarting at: $99.00
-
PHA 568487
PHA 568487 is an orally active and brain penetrant agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively). Learn MoreStarting at: $99.00
-
TCN 213
TCN 213 is a NMDA receptor antagonist, selective for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B. Learn MoreStarting at: $149.00
-
(±)-1-(1,2-Diphenylethyl)piperidine maleate
(±)-1-(1,2-Diphenylethyl)piperidine maleate is a high affinity antagonist at the ion channel on the NMDA receptor. Learn MoreStarting at: $85.00
-
TQS
TQS is a type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Learn MoreStarting at: $125.00
-
TCS 46b
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively), whih potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. Learn MoreStarting at: $109.00
-
S 24795
S 24795 is a partial agonist of α7 nAChR, which improves mnemonic function in aged mice for the treatment of aging-related memory disturbances and displays more efficient memory-enhancing effects than memantine in Alzheimer's disease mouse models. Learn MoreStarting at: $90.00
-
Spermine tetrahydrochloride
Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects. Learn MoreStarting at: $59.00
-
D-Serine
D-Serine is a glycine agonist at the NMDA receptor. L-Serine also available. Learn MoreStarting at: $79.00
-
DMAB-anabaseine dihydrochloride
DMAB-anabaseine dihydrochloride is a partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Learn MoreStarting at: $119.00
-
Spermidine trihydrochloride
Spermidine trihydrochloride binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801. Learn MoreStarting at: $65.00
-
(S)-(+)-Ketamine hydrochloride
(S)-(+)-Ketamine hydrochloride is a NMDA receptor antagonist, which displays neuroprotective efficacy in vitro. Learn MoreStarting at: $85.00
-
Norketamine hydrochloride
Norketamine hydrochloride is a major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Learn MoreStarting at: $99.00
-
Glycine
Glycine acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Learn MoreStarting at: $33.00