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Ion Channels
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PPADS tetrasodium salt
PPADS tetrasodium salt is a non-selective P2 purinergic antagonist, which blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. Learn MoreStarting at: $55.00
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iso-PPADS tetrasodium salt
iso-PPADS tetrasodium salt is a P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS. Learn MoreStarting at: $65.00
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BzATP triethylammonium salt
BzATP triethylammonium salt is a prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Learn MoreStarting at: $50.00
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A 804598
A 804598 is a potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively), which binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors). Learn MoreStarting at: $100.00
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NF 110
NF 110 is a high affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively), which potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM), and shows antitumor activity against several tumor types. Learn MoreStarting at: $135.00
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Ro 51
Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Learn MoreStarting at: $129.00
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NF 023
NF 023 is a subtype-selective, competitive and reversible P2X1 receptor antagonist, which selectively inhibits the α-subunit of Go/i (EC50 ~300 nM). Learn MoreStarting at: $105.00
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NF 157
NF 157 is a purinergic receptor antagonist that potently inhibits P2Y11 receptor activity (IC50 = 463 nM), which inhibits NAD+-induced activation of human granulocytes. Learn MoreStarting at: $129.00
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RO-3
RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Learn MoreStarting at: $105.00
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PPNDS
PPNDS is a potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Learn MoreStarting at: $89.00
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AZ 11645373
AZ 11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Learn MoreStarting at: $140.00
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YS-035 hydrochloride
YS-035 hydrochloride is a Ca2+ blocker that strikingly prolongs cardiac action potentials by inhibiting pacemaker current and K+ outward currents. Learn MoreStarting at: $79.00
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NF 449
NF 449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Learn MoreStarting at: $139.00
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ATPγS tetralithium salt
ATPγS tetralithium salt is a P2 purinergic receptor agonist. Learn MoreStarting at: $139.00
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AMTB hydrochloride
AMTB hydrochloride is a TRPM8 channel blocker that inhibits icilin- induced TRPM8 channel activation in a rat model. Learn MoreStarting at: $139.00
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TC-P 262
TC-P 262 is a selective P2X3 and P2X2/3 receptor antagonist (pIC50 values are 7.39 and 6.68 respectively). Learn MoreStarting at: $109.00
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5-BDBD
5-BDBD is a potent P2X4 receptor antagonist with an IC50 value of 0.50 μM. Learn MoreStarting at: $119.00
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Cesium chloride
Cesium chloride is a potassium channel blocker that prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β. Learn MoreStarting at: $39.00
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WS 12
WS 12 is a potent TRPM8 agonist that acts as a cooling agent with EC50 value of 193 nM. Learn MoreStarting at: $99.00
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TNP-ATP triethylammonium salt
TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist that inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Learn MoreStarting at: $189.00
