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Ion Channels
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UBP 302
UBP 302, an active enantiomer of UBP 296, is a selective and potent GLUK5 (GluR5)-subunit containing kainate receptor antagonist that displays ~ 260-fold selectivity over AMPA receptors and ~ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors. Learn MoreStarting at: $195.00
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UBP 296
UBP 296 is a selective GluR5-subunit containing kainate receptor antagonist that displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Learn MoreStarting at: $149.00
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NS 3763
NS 3763 is a selective non-competitive kainate receptor antagonist that displays selectivity for GLUK5 subunit-containing receptors with IC50 values of 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively. Learn MoreStarting at: $99.00
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Gadolinium chloride
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist and induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Learn MoreStarting at: $39.00
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β-Alanine
β-Alanine is a non-specific endogenous agonist at the inhibitory glycine receptor. More selective than taurine, which slso distinguishes between GABA transporters (IC50 values are 19, 58, 110, 1320 and 5690 μM for rGAT-2, hGAT-3, rGAT-3, hBGT-3 and hGAT-1 respectively). Learn MoreStarting at: $49.00
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YM 58483
YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes) and inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Learn MoreStarting at: $145.00
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Hypotaurine
Endogenous inhibitory amino acid. Learn MoreStarting at: $75.00
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ML SA1
ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Learn MoreStarting at: $75.00
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MRS 1845
MRS 1845 is potent blocker of store-operated Ca2+ channels and inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM). Learn MoreStarting at: $120.00
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L-Alanine
L-Alanine is an Agonist at the inhibitory glycine receptor. Learn MoreStarting at: $33.00
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L-Serine
L-Serine is an endogenous agonist at the inhibitory glycine receptor. Learn MoreStarting at: $33.00
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MNI-caged-L-glutamate
MNI-caged-L-glutamate is a MNI-caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation). Learn MoreStarting at: $139.00
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Benzoquinonium dibromide
Benzoquinonium dibromide is a nicotinic antagonist, ganglion blocker, which activates single channels but blocks open channels at nicotinic receptors. Learn MoreStarting at: $90.00
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(-)-Cotinine
Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum, and displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model. Learn MoreStarting at: $65.00
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L-BMAA hydrochloride
PNU 22394 hydrochloride is a potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Learn MoreStarting at: $65.00
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Carbamoylcholine chloride
Carbamoylcholine chloride is a cholinergic receptor agonist that is resistant to the action of cholinesterases. Learn MoreStarting at: $59.00
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3-Bromocytisine
3-Bromocytisine is a potent agonist of α4β4, α4β2 and α7 nACh receptors (IC50 values are 0.28, 0.30 and 31.6 nM respectively), which displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC50 values are 0.008 and 0.05 μM respectively). Learn MoreStarting at: $140.00
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(±)-Epibatidine
(±)-Epibatidine is a very potent nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Learn MoreStarting at: $180.00
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N-Acetylglycyl-D-glutamic acid
N-Acetylglycyl-D-glutamic acid is an excitatory peptide, more potent than L-glutamic acid at inducing seizures in mice. Learn MoreStarting at: $80.00
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(-)-Lobeline hydrochloride
(-)-Lobeline hydrochloride is a high affinity nicotinic receptor ligand, with a Ki value of 4.4 nM in rat brain. Learn MoreStarting at: $55.00
