Ion Channels
-
AZ 10606120 dihydrochloride
AZ 10606120 dihydrochloride is a potent P2X7 receptor antagonist that binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Learn MoreStarting at: $121.00
-
2-APB
2-APB is a functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist with IC50 = 42 μM. Learn MoreStarting at: $45.00
-
DMP 543
Indirubin-3'-oxime is aprotein kinase inhibitor and inhibits cyclin-dependent kinases (IC50 = 0.18 - 3.33 μM) and GSK-3β (IC50 = 0.19 μM). Learn MoreStarting at: $95.00
-
9-Phenanthrol
9-Phenanthrol is a selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells), which exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Learn MoreStarting at: $49.00
-
2-Methylthioadenosine triphosphate tetrasodium salt
2-Methylthioadenosine triphosphate tetrasodium salt is a P2 purinoceptor agonist. Learn MoreStarting at: $179.00
-
WS 3
WS 3 is a cooling agent that is an agonist at TRPM8 receptors (EC50 = 3.7 μM). Learn MoreStarting at: $69.00
-
GYKI 53655 hydrochloride
GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist, which blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. Learn MoreStarting at: $135.00
-
YM 90K hydrochloride
YM 90K hydrochloride is a selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. Learn MoreStarting at: $150.00
-
SYM 2206
SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50 = 2.8 μM ). Learn MoreStarting at: $125.00
-
S 18986
S 18986 is a positive allosteric modulator of AMPA receptors which exhibits cognitive enhancing properties in rodent behavioral models. Learn MoreStarting at: $135.00
-
CFM-2
CFM-2 is a novel, selective non-competitive AMPA antagonist. Learn MoreStarting at: $135.00
-
SIB 1553A hydrochloride
SIB 1553A hydrochloride is a nicotinic acetylcholine receptor (nAChR) agonist which displays selectivity for β4 subunit-containing receptors. Learn MoreStarting at: $105.00
-
CP 465022 hydrochloride
CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity, which also significantly blocks the persistent component of Nav1.6 channel activity. Learn MoreStarting at: $110.00
-
PEPA
PEPA is a novel allosteric potentiator of AMPA receptor desensitization. Learn MoreStarting at: $105.00
-
(S)-(-)-5-Fluorowillardiine
(S)-(-)-5-Fluorowillardiine is a more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). Learn MoreStarting at: $140.00
-
NPEC-caged-(S)-AMPA
NPEC-caged-(S)-AMPA is a 1-(2-nitrophenyl)ethyl caged version of (S)-AMPA. Learn MoreStarting at: $215.00
-
Naspm trihydrochloride
Naspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors, which blocks AMPA receptors lacking the GluR2 subunit, and protects hippocampal neurons against global ischemia-induced cell death. Learn MoreStarting at: $140.00
-
GYKI 47261 dihydrochloride
GYKI 47261 dihydrochloride is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM), which displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo. Learn MoreStarting at: $135.00
-
IEM 1460
IEM 1460 is a voltage-dependent open-channel blocker of AMPA receptors which displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors (IC50 values are 2.6 and 1102 μM respectively). Learn MoreStarting at: $85.00
-
NBQX disodium salt
NBQX disodium salt is a potent, selective and competitive AMPA receptor antagonist. Learn MoreStarting at: $75.00