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5-HT2 Receptors
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DOI hydrochloride
Brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively), which reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Learn MoreStarting at: $90.00
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TCB-2
TCB-2 is a high affinity 5-HT2A receptor agonist that potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors with an EC50 value of 36 nM. Learn MoreStarting at: $139.00
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Altanserin hydrochloride
Altanserin hydrochloride is a potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Learn MoreStarting at: $95.00
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Fananserin
Fananserin is a 5-HT2A receptor antagonist that also displays high affinity at D4 receptors (Ki values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1, α1, 5-HT1A and D2 receptors respectively). Learn MoreStarting at: $95.00
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DV 7028 hydrochloride
DV 7028 hydrochloride is a selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Learn MoreStarting at: $105.00
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Sarpogrelate hydrochloride
Sarpogrelate hydrochloride is a selective 5-HT2A receptor antagonist (pKi values are 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively), which displays selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Learn MoreStarting at: $100.00
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4F 4PP oxalate
4F 4PP oxalate is a selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM). Learn MoreStarting at: $98.00
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Zotepine
Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Learn MoreStarting at: $65.00
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MDL 11,939
MDL 11,939 is an Orally active 5-HT2A receptor antagonist, which displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively). Learn MoreStarting at: $105.00
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AT 1015
AT 1015 is a long-acting 5-HT2A receptor antagonist which inhibits vasoconstriction and blocks platelet aggregation. Learn MoreStarting at: $115.00
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LY 272015 hydrochloride
LY 272015 hydrochloride is a high affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Learn MoreStarting at: $135.00
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m-CPP hydrochloride
m-CPP hydrochloride is a 5-HT2C/2B receptor agonist/partial agonist with pEC50 values of 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT2C, 2B and 2A, bovine 5-HT1A and rat 5-HT1B receptors respectively. Learn MoreStarting at: $38.00
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BW 723C86 hydrochloride
DMP 543 is a K+ channel blocker and acetylcholine release stimulator, which potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Learn MoreStarting at: $95.00
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SDZ SER 082 fumarate
SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors which inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8, and Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34). Learn MoreStarting at: $135.00
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LY 266097 hydrochloride
LY 266097 hydrochloride is a selective 5-HT2B receptor antagonist (pKi = 9.3). Learn MoreStarting at: $135.00
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SB 204741
SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95) which displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors. Learn MoreStarting at: $115.00
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α-Methyl-5-hydroxytryptamine maleate
α-Methyl-5-hydroxytryptamine maleate is a 5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively. Learn MoreStarting at: $75.00
