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Potassium Channels
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NS 11021
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Learn MoreStarting at: $139.00
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Penitrem A
Penitrem A is a potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing α subunits only, and those containing α and β1 respectively), which blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo. Learn MoreStarting at: $75.00
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1-EBIO
1-EBIO is an activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. And it also induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Learn MoreStarting at: $65.00
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SKA 31
SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Learn MoreStarting at: $85.00
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NS 5806
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito), which increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM), and inhibits KV1.4-mediated currents independently of KChIP2. Learn MoreStarting at: $149.00
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NS 3623
NS 3623 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, which activates the IKr current and displays antiarrhythmic activity and exhibits potential dual mode of action at the hERG inhibitory site; may also act as a partial blocker of KV11.1 (hERG) channels. Learn MoreStarting at: $145.00
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ICA 110381
ICA 110381 is a KV7.2/7.3 activator (EC50 = 0.38 μM), which decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures. Learn MoreStarting at: $99.00
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PD 118057
PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, which displays no major effect on INa, ICa/L, IK1 and IKs currents. Learn MoreStarting at: $119.00
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CP 339818 hydrochloride
CP 339818 hydrochloride is a potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM), which inhibits KV1.4 with an IC50 of ~ 300 nM. Learn MoreStarting at: $120.00
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AM 92016 hydrochloride
AM 92016 hydrochloride is a specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity which exhibits proarrhythmic and prohypertensive activity in vivo. Learn MoreStarting at: $110.00
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UK 78282 hydrochloride
UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Learn MoreStarting at: $135.00
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XE 991 dihydrochloride
XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Learn MoreStarting at: $110.00
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Linopirdine dihydrochloride
Linopirdine dihydrochloride is a blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM). Learn MoreStarting at: $115.00
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DPO-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5), which displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Learn MoreStarting at: $105.00
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NS 1643
NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM), which exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Learn MoreStarting at: $90.00
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JNJ 303
JNJ 303 is a potent IKs blocker with an IC50 of 64 nM. Learn MoreStarting at: $125.00
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RuBi-4AP
RuBi-4AP is a water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Learn MoreStarting at: $119.00
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Psora 4
Psora 4 is a potent KV1.3 channel blocker (EC50 = 3 nM) that preferentially binds the C-type inactivated state of the channel. Learn MoreStarting at: $145.00
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ICA 069673
ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) potassium channel opener with EC50 of 0.69 μM. Learn MoreStarting at: $119.00
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Tetraethylammonium chloride
Tetraethylammonium chloride is a non-selective K+ channel blocker. Learn MoreStarting at: $39.00
