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Glutamate (Metabotropic) Receptors
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Ro 01-6128
Ro 01-6128 is a positive allosteric modulator of mGlu1 receptors, which potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a). Learn MoreStarting at: $85.00
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Desmethyl-YM 298198
Desmethyl-YM 298198 is a derivative of the mGlu1-selective antagonist YM 298198. Learn MoreStarting at: $139.00
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YM 202074
High affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist which binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Learn MoreStarting at: $139.00
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Ro 67-7476
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors which potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Learn MoreStarting at: $129.00
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VU 0285683
VU 0285683 is a negative allosteric modulator of mGlu5 receptors, which displays high affinity for the MPEP binding site and acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Learn MoreStarting at: $125.00
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LY 367385
LY 367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu5a, and negligible action on group II and III receptors. Learn MoreStarting at: $119.00
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DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
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NPS 2390
NPS 2390is a group I mGlu antagonist which displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Learn MoreStarting at: $119.00
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Bay 36-7620
Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity, which exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration. Learn MoreStarting at: $155.00
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(S)-3,4-DCPG
(S)-3,4-DCPG is a potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7, which increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Learn MoreStarting at: $140.00
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ACPT-I
ACPT-I is an agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Learn MoreStarting at: $140.00
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CPPG
CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). Learn MoreStarting at: $115.00
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TC-N 22A
TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Learn MoreStarting at: $135.00
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VU 0155041 sodium salt
VU 0155041 sodium salt is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Learn MoreStarting at: $50.00
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NPEC-caged-(S)-3,4-DCPG
NPEC-caged-(S)-3,4-DCPG is a (S)-3,4-DCPG caged with the photosensitive 1-(2-nitrophenyl)ethoxycarbonyl group. Learn MoreStarting at: $215.00
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(RS)-PPG
(RS)-PPG is a potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8. Learn MoreStarting at: $100.00
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VU 0155041
VU 0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Learn MoreStarting at: $120.00
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TCN 238
TCN 238 is a positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Learn MoreStarting at: $105.00
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UBP1112
UBP1112 is a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors). Learn MoreStarting at: $139.00
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Z-Cyclopentyl-AP4
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. And selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Learn MoreStarting at: $129.00
