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Glutamate (Metabotropic) Group I Receptors
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Ro 67-4853
Ro 67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor) which exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Learn MoreStarting at: $90.00
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Ro 01-6128
Ro 01-6128 is a positive allosteric modulator of mGlu1 receptors, which potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a). Learn MoreStarting at: $85.00
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Desmethyl-YM 298198
Desmethyl-YM 298198 is a derivative of the mGlu1-selective antagonist YM 298198. Learn MoreStarting at: $139.00
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YM 202074
High affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist which binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Learn MoreStarting at: $139.00
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Ro 67-7476
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors which potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Learn MoreStarting at: $129.00
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Bay 36-7620
Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity, which exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration. Learn MoreStarting at: $155.00
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NPS 2390
NPS 2390is a group I mGlu antagonist which displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Learn MoreStarting at: $119.00
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DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
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LY 367385
LY 367385 is a selective mGlu1a receptor antagonist, with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu5a, and negligible action on group II and III receptors. Learn MoreStarting at: $119.00
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(1S,3R)-ACPD
(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively). Learn MoreStarting at: $170.00
