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Glutamate (Metabotropic) Group I Receptors
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DCB
DCB is an allosteric ligand for the metabotropic glutamate receptor mGlu5 that displays neutral modulation. Learn MoreStarting at: $70.00
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CPPHA
CPPHA is a positive allosteric modulator at mGlu1 and mGlu5. Learn MoreStarting at: $159.00
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(±)-trans-ACPD
(±)-trans-ACPD, equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD, is a selective agonist for metabotropic glutamate receptors. Learn MoreStarting at: $139.00
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Fenobam
Fenobam is a potent and selective non-competitive mGlu5 antagonist that displays inverse agonist properties and blocks mGlu5 constitutive activity in vitro with IC50 of 87 nM. Learn MoreStarting at: $96.00
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HexylHIBO
HexylHIBO is a group I mGlu receptor antagonist (Ki values are 140 and 110 μM at mGlu1a and mGlu5a receptors respectively), which decreases sEPSCs in rat pyramidal neurons in vitro. Learn MoreStarting at: $129.00
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VU 0285683
VU 0285683 is a negative allosteric modulator of mGlu5 receptors, which displays high affinity for the MPEP binding site and acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Learn MoreStarting at: $125.00
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(S)-MCPG
(S)-MCPG is a active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist. Learn MoreStarting at: $185.00
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(RS)-MCPG
(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist. Learn MoreStarting at: $95.00
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(S)-4-Carboxyphenylglycine
(S)-4-Carboxyphenylglycine is a competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu1a/1a over mGlu5a/5b. Learn MoreStarting at: $135.00
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NPEC-caged-(1S,3R)-ACPD
NPEC-caged-(1S,3R)-ACPD is a(1S,3R)-ACPD caged with the photosensitive 1-(2-nitrophenyl)ethoxycarbonyl (NPEC) group. Learn MoreStarting at: $199.00
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VU 0360172 hydrochloride
VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Learn MoreStarting at: $105.00
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(RS)-MCPG disodium salt
(RS)-MCPG disodium salt is a sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist. Learn MoreStarting at: $95.00
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CHPG Sodium salt
CHPG Sodium salt is a sodium salt of the selective mGlu5 agonist CHPG. Learn MoreStarting at: $90.00
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VU 0360223
VU 0360223 is a potent negative allosteric modulator of mGlu5 (IC50 = 61 nM). Displays no activity at mGlu1-4 and mGlu7-8. Learn MoreStarting at: $120.00
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MFZ 10-7
MFZ 10-7 is a high affinity negative allosteric modulator at the mGlu5 receptor (Ki = 0.67 nM), which potently inhibits mGlu5 glutamate-mediated calcium mobilization (IC50 = 1.22 nM). Learn MoreStarting at: $105.00
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MTEP hydrochloride
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM), which displays anxiolytic activity in vivo and is orally active. Learn MoreStarting at: $90.00
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DFB
DFB is a novel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Learn MoreStarting at: $70.00
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CPCCOEt
CPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist (IC50 = 6.5 μM). Learn MoreStarting at: $105.00
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(RS)-3,5-DHPG
(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Learn MoreStarting at: $49.00
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(RS)-3-Hydroxyphenylglycine
(RS)-3-Hydroxyphenylglycine is an agonist at PI-linked metabotropic glutamate receptors. Separate isomer (S)-3-Hydroxyphenylglycine also available. Learn MoreStarting at: $99.00
