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Glutamate (Ionotropic) Receptors
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Domoic acid
Domoic acid is more potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies. Learn MoreStarting at: $110.00
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ATPA
ATPA is a selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Learn MoreStarting at: $140.00
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(S)-(-)-5-Iodowillardiine
(S)-(-)-5-Iodowillardiine demonstrates high affinity for the kainate receptor subtype hGluR5 (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6. Learn MoreStarting at: $135.00
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ACET
ACET is a potent and selective GluR5-containing kainate receptor antagonist that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Learn MoreStarting at: $275.00
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SYM 2081
SYM 2081 is a potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Learn MoreStarting at: $139.00
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Kainic acid
Kainic acid is a selective agonist at kainate receptors. Potent excitant and neurotoxin. Learn MoreStarting at: $65.00
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UBP 301
UBP 301 is a potent kainate receptor antagonist that displays ~ 30-fold selectivity over AMPA receptors. Learn MoreStarting at: $139.00
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NS 3763
NS 3763 is a selective non-competitive kainate receptor antagonist that displays selectivity for GLUK5 subunit-containing receptors with IC50 values of 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively. Learn MoreStarting at: $99.00
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UBP 296
UBP 296 is a selective GluR5-subunit containing kainate receptor antagonist that displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Learn MoreStarting at: $149.00
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UBP 302
UBP 302, an active enantiomer of UBP 296, is a selective and potent GLUK5 (GluR5)-subunit containing kainate receptor antagonist that displays ~ 260-fold selectivity over AMPA receptors and ~ 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors. Learn MoreStarting at: $195.00
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UBP 310
UBP 310 is a GLUK5 kainate receptor antagonist that also blocks recombinant homomeric GLUK7 receptors and displays 12,700-fold selectivity for GLUK5 over GLUK6. Learn MoreStarting at: $109.00
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2,4-Dihydroxyphenylacetyl-L-asparagine
2,4-Dihydroxyphenylacetyl-L-asparagine is a constituent of various spider toxins. Which has been reported to be specific blocker of glutamate receptors. Learn MoreStarting at: $135.00
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Lamotrigine isethionate
Lamotrigine isethionate is a water-soluble salt of lamotrigine, and displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Learn MoreStarting at: $90.00
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MNI-caged-L-glutamate
MNI-caged-L-glutamate is a MNI-caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation). Learn MoreStarting at: $139.00
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L-BMAA hydrochloride
PNU 22394 hydrochloride is a potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Learn MoreStarting at: $65.00
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Salsolinol-1-carboxylic acid
Salsolinol-1-carboxylic acid is an amino acid that occurs naturally in the CNS. Learn MoreStarting at: $95.00
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N-Acetylglycyl-D-glutamic acid
N-Acetylglycyl-D-glutamic acid is an excitatory peptide, more potent than L-glutamic acid at inducing seizures in mice. Learn MoreStarting at: $80.00
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(±)-LY 395756
(±)-LY 395756, an analog of LY 354740, is a selective metabotropic glutamate ligand for mGlu2 and mGlu3 receptors. Learn MoreStarting at: $199.00
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L-AP6
L-AP6 is a selective agonist for 'quis'-sensitized site. Learn MoreStarting at: $179.00
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CFM-2
CFM-2 is a novel, selective non-competitive AMPA antagonist. Learn MoreStarting at: $135.00
