Glycogen Synthase Kinase 3
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TCS 2002
TCS 2002 is a potent inhibitor of GSK-3β (IC50 = 35 nM), that inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. Learn MoreStarting at: $129.00
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TC-G 24
TC-G 24 is a potent GSK-3β inhibitor (IC50 = 17 nM), which displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Learn MoreStarting at: $135.00
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A 1070722
A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) which displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Learn MoreStarting at: $135.00
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3F8
L-755,507 is a potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Learn MoreStarting at: $115.00
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Indirubin-3'-oxime
ARL 67156 trisodium salt is a selective ecto-ATPase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively). Learn MoreStarting at: $110.00
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BIO
BIO is a potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor that maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro and also promotes proliferation and dedifferentiation in cardiomyocytes. Learn MoreStarting at: $109.00
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BIO-acetoxime
BIO-acetoxime is a selective GSK-3α/β inhibitor that induces Wnt signaling and inhibits CD8+ T cell effector differentiation. Learn MoreStarting at: $89.00
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MeBIO
MeBIO is an Aryl hydrocarbon receptor (AhR) agonist that causes redistribution of AhR to the nucleus. Learn MoreStarting at: $119.00
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PF 04885614
PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel), which exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Learn MoreStarting at: $125.00