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Search results for 'AP 24534'
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PF 3644022
PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM) which inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Learn MoreStarting at: $180.00
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(+)-Igmesine hydrochloride
(+)-Igmesine hydrochloride is a selective σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM), which inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Learn MoreStarting at: $175.00
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DL-AP5 Sodium salt
DL-AP5 Sodium salt is a sodium salt of DL-AP5. Potent NMDA antagonist. Learn MoreStarting at: $69.00
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Cercosporamide
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Learn MoreStarting at: $115.00
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MG 132
MG 132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM) which inhibits TNF-α-induced NF-κB activation and IκBα degradation. Learn MoreStarting at: $75.00
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D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is a phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Learn MoreStarting at: $135.00
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(S)-Duloxetine hydrochloride
(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HTand NA reuptake respectively in cortical synaptosomes, which exhibits antidepressant and anxiolytic effects. Learn MoreStarting at: $45.00
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(RS)-(Tetrazol-5-yl)glycine
(RS)-(Tetrazol-5-yl)glycine is a potent NMDA receptor agonist, approximately 20 times more active than NMDA. Learn MoreStarting at: $140.00
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BD 1047 dihydrobromide
BD 1047 dihydrobromide is a σ1 receptor antagonist, exhibiting a similar binding profile to that of BD 1063 but with higher affinity (approximately 10-fold) at both σ1 and σ2 sites. Learn MoreStarting at: $90.00
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Diprenorphine
Diprenorphine is a non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors). Learn MoreStarting at: $125.00
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Vinblastine sulfate
Vinblastine sulfate is an anticancer agent; microtubule disrupter which induces apoptosis in cultured hepatocytes and human lymphoma cells. Learn MoreStarting at: $80.00
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Clobenpropit dihydrobromide
Clobenpropit dihydrobromide is an extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93), which displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. Learn MoreStarting at: $115.00
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MR 16728 hydrochloride
This analog of cetiedil stimulates the release of acetylcholine from synaptosomes. Learn MoreStarting at: $105.00
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DCG IV
DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors. Learn MoreStarting at: $135.00
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SB 205607 dihydrobromide
SB 205607 dihydrobromide is the first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively). Learn MoreStarting at: $175.00
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ML 10302 hydrochloride
ML 10302 hydrochloride is a potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo. Learn MoreStarting at: $80.00
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BD 1063 dihydrochloride
BD 1063 dihydrochloride is a σ1 receptor antagonist, approximately 50-fold selective over σ2 sites and ≥100-fold selective over opioid, PCP, muscarinic, dopamine, α1, α2, β adrenoceptor, 5-HT1 and 5-HT2 receptors. Learn MoreStarting at: $85.00
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DEA
DEA is a potent endocannabinoid and anandamide analog that activates CB1 receptors in microglia and binds to rat synaptosomal membranes (Ki = 34.4 nM). Learn MoreStarting at: $80.00
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SR 49059
SR 49059 is a potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity, which displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors. Learn MoreStarting at: $225.00
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LY 303511
LY 303511 is a negative control compound with respect to LY 294002 PI 3-kinase inhibitory activity which blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Learn MoreStarting at: $75.00
