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Search results for 'AP 24534'
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SB 590885
SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM), which is elective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively), and decreases anchorage-independent growth of melanoma cell lines. It also inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. Learn MoreStarting at: $159.00
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Cyclapolin 9
Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM). Learn MoreStarting at: $105.00
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API-1
API-1 is an Akt/protein kinase B (PKB) inhibitor, which binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation, and inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Learn MoreStarting at: $229.00
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KH 7
KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo), which inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM, and locks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM. Learn MoreStarting at: $109.00
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PD 180970
PD 180970 is a ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells, and inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Learn MoreStarting at: $155.00
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Adaphostin
Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM), which induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro and displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro. Learn MoreStarting at: $98.00
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DCA
DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK), which shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria, and induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Learn MoreStarting at: $55.00
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NS 2028
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM), which inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC). Learn MoreStarting at: $139.00
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C 75
C 75 is a synthetic inhibitor of fatty acid synthase (FAS) which inhibits fatty acid synthesis in vitro and in vivo and displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity. Learn MoreStarting at: $135.00
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TAME hydrochloride
TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Learn MoreStarting at: $39.00
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LY 303511
LY 303511 is a negative control compound with respect to LY 294002 PI 3-kinase inhibitory activity which blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Learn MoreStarting at: $75.00
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D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is a phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Learn MoreStarting at: $135.00
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Cercosporamide
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Learn MoreStarting at: $115.00
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PF 3644022
PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM) which inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Learn MoreStarting at: $180.00
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Ro 31-8220 mesylate
Ro 31-8220 mesylate is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Learn MoreStarting at: $95.00
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GGTI 298
GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Learn MoreStarting at: $145.00
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Topotecan hydrochloride
Topotecan hydrochloride is a DNA topoisomerase I inhibitor which induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Learn MoreStarting at: $45.00
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IKK 16
IKK 16 is a selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively), which inhibits TNF-α-stimulated IκB degradation and LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis. Learn MoreStarting at: $125.00
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8-pCPT-2-O-Me-cAMP-AM
8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog which induces Rap activation and junction tightening in HUVECs. Learn MoreStarting at: $150.00
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U0126
U0126 is a Potent and selective non-competitive inhibitor of MAP kinase kinase, which inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Learn MoreStarting at: $135.00
