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Search results for 'AP 24534'
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NSC 687852
NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitylating enzymes (DUBs), UCHL5 and USP14. Learn MoreStarting at: $95.00
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Phenserine
Phenserine is a Physostigmine analog that inhibits acetylcholinesterase.Phenserin also inhibits production of amyloid precursor protein (APP) and A&beta and improves morris water maze performance of scopolamine-treated rats. Learn MoreStarting at: $95.00
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Olomoucine
Olomoucine is a cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase and selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM) and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase. Learn MoreStarting at: $99.00
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(R)-DRF053 dihydrochloride
(R)-DRF053 dihydrochloride is a potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively), which also shown to inhibit amyloid-β production in N2A-APP695 cells. Learn MoreStarting at: $140.00
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EIT hydrobromide
EIT hydrobromide is a potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively). Learn MoreStarting at: $50.00
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SK1-I
SK1-I is a sphingosine kinase (SphK) inhibitor which inhibits the growth of both U937 and Jurkat T cells, and suppresses proliferation and induces apoptosis in several human glioblastoma cell lines. Learn MoreStarting at: $180.00
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KT 5720
KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Learn MoreStarting at: $165.00
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U0126
U0126 is a Potent and selective non-competitive inhibitor of MAP kinase kinase, which inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Learn MoreStarting at: $135.00
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8-pCPT-2-O-Me-cAMP-AM
8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog which induces Rap activation and junction tightening in HUVECs. Learn MoreStarting at: $150.00
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IKK 16
IKK 16 is a selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively), which inhibits TNF-α-stimulated IκB degradation and LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis. Learn MoreStarting at: $125.00
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Topotecan hydrochloride
Topotecan hydrochloride is a DNA topoisomerase I inhibitor which induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Learn MoreStarting at: $45.00
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GGTI 298
GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Learn MoreStarting at: $145.00
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Ro 31-8220 mesylate
Ro 31-8220 mesylate is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Learn MoreStarting at: $95.00
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PF 3644022
PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM) which inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Learn MoreStarting at: $180.00
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Cercosporamide
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Learn MoreStarting at: $115.00
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D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is a phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Learn MoreStarting at: $135.00
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LY 303511
LY 303511 is a negative control compound with respect to LY 294002 PI 3-kinase inhibitory activity which blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Learn MoreStarting at: $75.00
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TAME hydrochloride
TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Learn MoreStarting at: $39.00
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C 75
C 75 is a synthetic inhibitor of fatty acid synthase (FAS) which inhibits fatty acid synthesis in vitro and in vivo and displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity. Learn MoreStarting at: $135.00
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NS 2028
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM), which inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC). Learn MoreStarting at: $139.00
