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Search results for 'as'
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PF 04217903 mesylate
PF 04217903 mesylate is a highly selective, high affinity c-Met inhibitor that displays >1000-fold selectivity for c-Met over a panel of 208 kinases. Learn MoreStarting at: $189.00
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A 83-01
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 . Learn MoreStarting at: $135.00
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5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) that displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma). Learn MoreStarting at: $119.00
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Demethylasterriquinone B1
Demethylasterriquinone B1 is a selective insulin receptor (IR) activator/mimetic that increases IR β subunit tyrosine phosphorylation and downstream activation of PI 3-kinase and Akt, but not ERK. Learn MoreStarting at: $169.00
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GW 441756
GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM), whih displays > 100-fold selectivity over a range of other kinases. Learn MoreStarting at: $139.00
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7,8-Dihydroxyflavone
7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). It inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Learn MoreStarting at: $119.00
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LM 22A4
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM), which induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome. Learn MoreStarting at: $129.00
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GTP 14564
GTP 14564 is a potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Learn MoreStarting at: $99.00
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A 286982
A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively). Learn MoreStarting at: $139.00
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Resiquimod
Resiquimod is a toll-like receptor 7 (TLR7) agonist which induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs), and inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Learn MoreStarting at: $50.00
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CU CPT 22
CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM), which inhibits the release of proinflammatory cytokines TNF-α and IL-1β. Learn MoreStarting at: $155.00
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RWJ 21757
RWJ 21757 is a Toll-like receptor 7 (TLR7) agonist which induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models. Learn MoreStarting at: $60.00
