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Search results for 'PR 171'
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5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) that displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma). Learn MoreStarting at: $119.00
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Alantolactone
Alantolactone induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction and displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells. Learn MoreStarting at: $125.00
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ANA 12
ANA 12 is a TrkB receptor antagonist, which demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Learn MoreStarting at: $135.00
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GR 144053 trihydrochloride
GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Learn MoreStarting at: $110.00
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Resiquimod
Resiquimod is a toll-like receptor 7 (TLR7) agonist which induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs), and inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Learn MoreStarting at: $50.00
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CU CPT 22
CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM), which inhibits the release of proinflammatory cytokines TNF-α and IL-1β. Learn MoreStarting at: $155.00
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RWJ 21757
RWJ 21757 is a Toll-like receptor 7 (TLR7) agonist which induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models. Learn MoreStarting at: $60.00
