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Search results for 'AG 490'
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TC-I 15
TC-I 15 is a potent α2β1 integrin inhibitor. IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively. Learn MoreStarting at: $169.00
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5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) that displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma). Learn MoreStarting at: $119.00
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YM 90709
S-Sulfo-L-cysteine sodium salt is an EAA receptor agonist. Learn MoreStarting at: $140.00
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RWJ 50271
CI 1020 is a highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Learn MoreStarting at: $135.00
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Poly(I:C)
Poly(I:C) is a synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Learn MoreStarting at: $79.00
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7,8-Dihydroxyflavone
7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). It inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Learn MoreStarting at: $119.00
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LM 22A4
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM), which induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome. Learn MoreStarting at: $129.00
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TCS 2314
Integrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM), which blocks the activation of inflammatory cells. Learn MoreStarting at: $139.00
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ANA 12
ANA 12 is a TrkB receptor antagonist, which demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Learn MoreStarting at: $135.00
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GR 144053 trihydrochloride
GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Learn MoreStarting at: $110.00
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Resiquimod
Resiquimod is a toll-like receptor 7 (TLR7) agonist which induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs), and inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Learn MoreStarting at: $50.00
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RWJ 21757
RWJ 21757 is a Toll-like receptor 7 (TLR7) agonist which induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models. Learn MoreStarting at: $60.00
