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Search results for 'AP 24534'
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FPA 124
FPA 124 is an Akt/PKB inhibitor that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Learn MoreStarting at: $125.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
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SKF 86002 dihydrochloride
SKF 86002 dihydrochloride is an inhibitor of p38 MAP kinase that potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM) and also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells. Learn MoreStarting at: $149.00
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(5Z)-7-Oxozeaenol
(5Z)-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Learn MoreStarting at: $109.00
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AEG 3482
AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling that binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Learn MoreStarting at: $89.00
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PIT 1
PIT 1, a selective PIP3 antagonist, blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03;M) and also inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Learn MoreStarting at: $119.00
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HI TOPK 032
HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor, which exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM). Learn MoreStarting at: $159.00
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AZM 475271
AZM 475271 is a src tyrosine kinase inhibitor, which reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Learn MoreStarting at: $179.00
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CMPD-1
CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of the two other known p38 substrates, MBP and ATF-2. Learn MoreStarting at: $119.00
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ACHP
ACHP is a IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively), which inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Learn MoreStarting at: $209.00
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SB 590885
SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM), which is elective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively), and decreases anchorage-independent growth of melanoma cell lines. It also inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. Learn MoreStarting at: $159.00
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Cyclapolin 9
Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM). Learn MoreStarting at: $105.00
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API-1
API-1 is an Akt/protein kinase B (PKB) inhibitor, which binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation, and inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Learn MoreStarting at: $229.00
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PD 180970
PD 180970 is a ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells, and inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Learn MoreStarting at: $155.00
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Adaphostin
Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM), which induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro and displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro. Learn MoreStarting at: $98.00
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DCA
DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK), which shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria, and induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Learn MoreStarting at: $55.00
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LY 303511
LY 303511 is a negative control compound with respect to LY 294002 PI 3-kinase inhibitory activity which blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Learn MoreStarting at: $75.00
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Cercosporamide
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Learn MoreStarting at: $115.00
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PF 3644022
PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM) which inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Learn MoreStarting at: $180.00
