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AMPA Receptors
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IEM 1460
IEM 1460 is a voltage-dependent open-channel blocker of AMPA receptors which displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors (IC50 values are 2.6 and 1102 μM respectively). Learn MoreStarting at: $85.00
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GYKI 47261 dihydrochloride
GYKI 47261 dihydrochloride is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM), which displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo. Learn MoreStarting at: $135.00
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Naspm trihydrochloride
Naspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors, which blocks AMPA receptors lacking the GluR2 subunit, and protects hippocampal neurons against global ischemia-induced cell death. Learn MoreStarting at: $140.00
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NPEC-caged-(S)-AMPA
NPEC-caged-(S)-AMPA is a 1-(2-nitrophenyl)ethyl caged version of (S)-AMPA. Learn MoreStarting at: $215.00
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(S)-(-)-5-Fluorowillardiine
(S)-(-)-5-Fluorowillardiine is a more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). Learn MoreStarting at: $140.00
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PEPA
PEPA is a novel allosteric potentiator of AMPA receptor desensitization. Learn MoreStarting at: $105.00
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GYKI 53655 hydrochloride
GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist, which blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. Learn MoreStarting at: $135.00
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YM 90K hydrochloride
YM 90K hydrochloride is a selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. Learn MoreStarting at: $150.00
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SYM 2206
SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50 = 2.8 μM ). Learn MoreStarting at: $125.00
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S 18986
S 18986 is a positive allosteric modulator of AMPA receptors which exhibits cognitive enhancing properties in rodent behavioral models. Learn MoreStarting at: $135.00
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CFM-2
CFM-2 is a novel, selective non-competitive AMPA antagonist. Learn MoreStarting at: $135.00
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CP 465022 hydrochloride
CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity, which also significantly blocks the persistent component of Nav1.6 channel activity. Learn MoreStarting at: $110.00
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Cl-HIBO
Cl-HIBO is a subtype-selective and strongly desensitising AMPA receptor agonist. Learn MoreStarting at: $179.00
