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5-HT1 Receptors
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MM 77 dihydrochloride
This ligand has uniquely high affinity and selectivity for the D3 receptor. Learn MoreStarting at: $95.00
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Cyanopindolol hemifumarate
Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist. Learn MoreStarting at: $99.00
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MDL 72832 hydrochloride
MDL 72832 hydrochloride is a potent ligand at 5-HT1A receptors, with mixed agonist and antagonist properties. Learn MoreStarting at: $90.00
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MDL 73005EF hydrochloride
MDL 73005EF hydrochloride is a potent and selective 5-HT1A receptor antagonist, which has partial agonist properties. Learn MoreStarting at: $90.00
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S 14506 hydrochloride
S 14506 hydrochloride is a highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Learn MoreStarting at: $135.00
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(S)-WAY 100135 dihydrochloride
(S)-WAY 100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Learn MoreStarting at: $110.00
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Buspirone hydrochloride
Buspirone hydrochloride is a classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). Learn MoreStarting at: $49.00
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PNU 142633
PNU 142633 is a very selective, high affinity 5-HT1D receptor agonist (Ki values are 6 and > 18000 nM at human 5-HT1D and 5-HT1B receptors respectively), which inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo. Learn MoreStarting at: $149.00
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PNU 109291
PNU 109291 is a potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Learn MoreStarting at: $155.00
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GR 46611
GR 46611 is a 5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands. Learn MoreStarting at: $120.00
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CP 135807
CP 135807 is a selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration. Learn MoreStarting at: $135.00
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GR 127935 hydrochloride
GR 127935 hydrochloride is a potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors) which displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Learn MoreStarting at: $155.00
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L-703,664 succinate
L-703,664 succinate is a 5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors). Learn MoreStarting at: $140.00
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L-694,247
L-694,247 is a selective and extremely potent 5-HT1D receptor agonist. Learn MoreStarting at: $135.00
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BRL 54443
BRL 54443 acts as a selective agonist for the 5-HT1E and 5-HT1F serotonin receptor subtypes with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors. Learn MoreStarting at: $92.00
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LY 344864 hydrochloride
LY 344864 hydrochloride is a potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Learn MoreStarting at: $130.00
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LY 334370 hydrochloride
LY 334370 hydrochloride is a selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Learn MoreStarting at: $140.00
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5-Carboxamidotryptamine maleate
5-Carboxamidotryptamine maleate is a 5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B , 5-HT1D, 5-ht5 and 5-HT7 receptors. Learn MoreStarting at: $139.00
