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Transporters

YM 244769

YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX) that inhibits Na+-dependent 45Ca2+ uptake with IC50 values of 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively. Learn More

Starting at: $125.00

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CGP 37157

CGP 37157 is a selective antagonist of the mitochondrial Na+-Ca2+ exchanger with an IC50 of 0.4 μM. Learn More

Starting at: $139.00

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OMDM-2

OMDM-2 is a metabolically stable inhibitor of anandamide cellular uptake that displays relatively low affinity for CB1 and CB2 receptors with Ki values of 5.1 and > 10 μM and for vanilloid VR1 receptors with EC50 value of 10 μM. Learn More

Starting at: $65.00

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Benzamil

Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 . Learn More

Starting at: $50.00

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O-2093

O-2093 is an inhibitor of anandamide uptake (IC50 = 17.3 μM) with little or no activity at CB1, CB2, TRPV1 and FAAH. Learn More

Starting at: $99.00

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SN-6

SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor which displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Learn More

Starting at: $115.00

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UCM 707

UCM 707 is a potent endocannabinoid transport inhibitor. IC50 values are 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH respectively. Ki values are 4700, 67 and > 5000 nM for CB1, CB2 and VR1 receptors respectively. Learn More

Starting at: $125.00

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VDM 11

VDM 11 is a potent and selective inhibitor of the anandamide membrane transporter (AMT) with IC50 values of 4-11 μM, which displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Learn More

Starting at: $75.00

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AM 1172

AM 1172 metabolically stable anandamide uptake inhibitor (IC50 = 2.1 - 2.5 μM) and fatty acid amide hydrolase (FAAH) inhibitor (Ki = 3.18 μM). Learn More

Starting at: $139.00

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AM 404

AM 404 is a competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available in water soluble emulsion . Learn More

Starting at: $65.00

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Talsupram hydrochloride

Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor which exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Learn More

Starting at: $129.00

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Desipramine hydrochloride

Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters with Ki values of 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively. Learn More

Starting at: $41.00

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Bicifadine hydrochloride

Bicifadine hydrochloride is an orally active, potent antagonist of the noradrenalin transporter with antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Learn More

Starting at: $139.00

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Talopram hydrochloride

Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) with selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Learn More

Starting at: $139.00

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Concanamycin A

Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. Learn More

Starting at: $99.00

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(±)-Vesamicol hydrochloride

(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM), which centrally active following systemic administration in vivo. Learn More

Starting at: $69.00

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Fumitremorgin C

Fumitremorgin is a chemosensitizing agent which selectively reverses BCRP-mediated multidrug resistance. Learn More

Starting at: $170.00

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CP 100356 hydrochloride

CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms) which inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Learn More

Starting at: $155.00

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Elacridar hydrochloride

P-glycoprotein (P-gp/ABCG1) inhibitor, which blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. It also inhibits breast cancer resistance protein (BCRP/ABCG2). Learn More

Starting at: $100.00

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XR 9051 HCl

XR 9051 HCl is a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) that inhibits the binding of cytotoxics to P-glycoprotein (EC50 = 134 nM). Learn More

Starting at: $135.00

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