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Transient Receptor Potential Channels
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BCTC
BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist, which inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Learn MoreStarting at: $109.00
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SB 452533
SB 452533 is a potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Learn MoreStarting at: $109.00
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SB 366791
SB 366791 is a potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Learn MoreStarting at: $109.00
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α-Spinasterol
α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM), which reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Learn MoreStarting at: $89.00
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5'-Iodoresiniferatoxin
5'-Iodoresiniferatoxin is a potent and silent vanilloid receptor antagonist that binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM. Learn MoreStarting at: $269.00
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AMG 9810
AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Learn MoreStarting at: $119.00
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Olvanil
Olvanil, a potent vanilloid receptor agonist, blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Learn MoreStarting at: $99.00
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JNJ 17203212
JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that inhibits capsaicin- and H+-induced channel activation and exhibits antitussive and analgesic activity in vivo. Learn MoreStarting at: $119.00
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RN 1747
RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively) which displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Learn MoreStarting at: $95.00
