Transferases
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CI 976
CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM), which inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM). Learn MoreStarting at: $95.00
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Fumonisin B1
Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme, which potently inhibits sphingosine N-acyltransferase (ceramide synthase) and inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively. Learn MoreStarting at: $70.00
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YM 750
YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM) which exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo. Learn MoreStarting at: $95.00
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VULM 1457
Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor which decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats. Learn MoreStarting at: $119.00
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OR-486
OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase. Learn MoreStarting at: $90.00
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CP 316819
CP 316819 is a selective glycogen phosphorylase inhibitor [IC50 values are 0.017 and 0.034 μM against human skeletal muscle glycogen phosphorylase a (huSMGPa) and liver glycogen phosphorylase a (huLGPa) respectively]. Learn MoreStarting at: $140.00
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GPi 688
GPi 688 is an allosteric glycogen phosphorylase inhibitor that inhibits glucagon-mediated hyperglycemia in vivo in the rat. Learn MoreStarting at: $179.00
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CRT 0066101
CRT 0066101 is a potent inhibitor of protein kinase D (PKD), which inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Learn MoreStarting at: $199.00
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FTI 276
RS 45041-190 hydrochloride is a highly selective I2 imidazoline receptor ligand. Learn MoreStarting at: $90.00
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GGTI 298
GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Learn MoreStarting at: $145.00
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Tunicamycin
Antibiotic; inhibits GlcNAc phosphotransferase (GPT), and blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Learn MoreStarting at: $100.00
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LDN 27219
LDN 27219 is a transglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible. Learn MoreStarting at: $119.00
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LY 78335
LY 78335 is a high affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro), which suppresses the release of growth hormone in an in vivo rat model. Learn MoreStarting at: $79.00
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Tris DBA
Tris DBA is a N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Learn MoreStarting at: $75.00
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Cystamine dihydrochloride
Cystamine dihydrochloride is a transglutaminase inhibitor.It decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Learn MoreStarting at: $29.00
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SKF 91488 dihydrochloride
SKF 91488 dihydrochloride is a strong inhibitor of histamine N-methyltransferase with no histamine agonist activity. Learn MoreStarting at: $69.00
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MIM1
MIM1 is an inhibitor of Mcl-1, which selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Learn MoreStarting at: $125.00