Retinoic Acid Receptors
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EC 23
EC 23 is Photostable synthetic retinoid and displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Learn MoreStarting at: $135.00
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AC 55649
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. Learn MoreStarting at: $99.00
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CD 2665
SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively) which displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. Learn MoreStarting at: $140.00
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BMS 453
R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist which displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM) and inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. Learn MoreStarting at: $135.00
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MM 11253
MM 11253 is a selective RARγ antagonist, which blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Learn MoreStarting at: $139.00
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BMS 195614
BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM) which displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Learn MoreStarting at: $159.00
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BMS 753
BMS 753 is a RARα-selective agonist (Ki = 2 nM). Learn MoreStarting at: $120.00
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BMS 493
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist, which enhances nuclear corepressor (NCoR) interaction with RARs. Learn MoreStarting at: $135.00
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ER 50891
ER 50891 is a antagonist of RARα receptors (IC50 = 31.2 nM), which displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively). Learn MoreStarting at: $155.00
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BMS 961
BMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Learn MoreStarting at: $135.00
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LE 135
LE 135 is a retinoic acid antagonist; displays moderate selectivity for RARβ over RARα Learn MoreStarting at: $105.00
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Ch 55
Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP) and Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Learn MoreStarting at: $90.00
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CD 1530
CD 1530 is a potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM). Learn MoreStarting at: $95.00
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AC 261066
AC 261066 is a potent RARβ2 agonist with a pEC50 value of 8.1. Learn MoreStarting at: $139.00