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Nuclear Receptors
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(Z)-4-Hydroxytamoxifen
(Z)-4-Hydroxytamoxifen is an estrogen receptor antagonist. Learn MoreStarting at: $139.00
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α-Estradiol
α-Estradiol is a endogenous estrogen receptor ligand. Learn MoreStarting at: $49.00
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ERB 041
IC50 values of ERB 041 are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively. Learn MoreStarting at: $139.00
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(R)-DPN
(R)-DPN, a enantiomer of DPN, displays higher affinity for estrogen receptor (ER) β over ERα with Ki values of 1.82 and 147 nM respectively . Learn MoreStarting at: $186.00
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SR 202
SR 202 is a selective PPARγ antagonist that inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Learn MoreStarting at: $90.00
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Pioglitazone hydrochloride
Pioglitazone hydrochloride is a selective PPARγ agonist (EC50 = 0.69 μM). Learn MoreStarting at: $45.00
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GW 1929 hydrochloride
GW 1929 hydrochloride is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Learn MoreStarting at: $135.00
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S26948
S26948 is a selective PPARγ agonist (EC50 = 8.83 nM), which drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice, and displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats. Learn MoreStarting at: $139.00
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BADGE
RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. Learn MoreStarting at: $80.00
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Ciglitazone
Ciglitazone is a selective agonist at PPAR&gamma with an EC50 value of 3 μM in vivo. Learn MoreStarting at: $139.00
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nTZDpa
nTZDpa is a potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ~25% maximum efficacy. Learn MoreStarting at: $100.00
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TCPOBOP
TCPOBOP is an agonist of the constitutive androstane receptor that induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Learn MoreStarting at: $79.00
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CITCO
CITCO is a constitutive androstane receptor (CAR) agonist (EC50 = 49 nM), which displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Learn MoreStarting at: $89.00
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CP 775146
CP 775146 is a selective, high affinity PPARα agonist with Ki values of 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Learn MoreStarting at: $169.00
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DiMNF
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM) which suppresses expression of CD55 and CD46 induced by IL-1β Learn MoreStarting at: $110.00
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L-Kynurenine
Tryptophan catabolite; endogenous activator of the aryl hydrocarbon receptor (AhR). Learn MoreStarting at: $39.00
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CH 223191
CH 223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist, which displays no AhR agonist activity (at concentrations up to 100 μM) and blocks binding of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to the AhR in a dose-dependent manner. Learn MoreStarting at: $109.00
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Phortress
Phortress is a prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Learn MoreStarting at: $155.00
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ITE
ITE is an endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); Ki = 3 nM for binding to murine AHR. Learn MoreStarting at: $139.00
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6,2',4'-Trimethoxyflavone
6,2',4'-Trimethoxyflavone is an aryl hydrocarbon receptor antagonist with EC50 value of 0.9 μM. Learn MoreStarting at: $85.00
