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Nuclear Receptors
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CD 1530
CD 1530 is a potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM). Learn MoreStarting at: $95.00
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Ch 55
Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP) and Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Learn MoreStarting at: $90.00
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LE 135
LE 135 is a retinoic acid antagonist; displays moderate selectivity for RARβ over RARα Learn MoreStarting at: $105.00
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BMS 961
BMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Learn MoreStarting at: $135.00
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ER 50891
ER 50891 is a antagonist of RARα receptors (IC50 = 31.2 nM), which displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively). Learn MoreStarting at: $155.00
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UVI 3003
UVI 3003 is a RXR antagonist that displays high RXR binding affinity. Learn MoreStarting at: $115.00
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Docosahexaenoic acid
Docosahexaenoic acid is a endogenous omega-3 fatty acid. It acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Learn MoreStarting at: $75.00
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LG 101506
LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively), which displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Learn MoreStarting at: $139.00
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CD 3254
CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. Learn MoreStarting at: $135.00
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HX 630
HX 630 is a RXR agonist, which acts as a retinoid synergist and enhances the potency of AM 80 in a HL-60 cell differentiation assay. Learn MoreStarting at: $149.00
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HX 531
HX 531 is a potent RXR antagonist (IC50 = 18 nM). Learn MoreStarting at: $149.00
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LG 100754
LG 100754 is a novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity which displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Learn MoreStarting at: $140.00
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SR 11237
SR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity. Learn MoreStarting at: $135.00
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Fluorobexarotene
Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors), which displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene. Learn MoreStarting at: $160.00
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Guggulsterone
Guggulsterone is a broad spectrum steroid receptor ligand that binds with high affinity to mineralocorticoid receptors and lower affinity to progesterone, androgen and glucocorticoid receptors. Learn MoreStarting at: $109.00
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SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
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Z-Guggulsterone
Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Learn MoreStarting at: $139.00
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GC 1
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively), which displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Learn MoreStarting at: $115.00
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DLPC
DLPC is a selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro, which induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose, and exhibits antidiabetic effects. Learn MoreStarting at: $50.00
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AC 45594
AC 45594 is a selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM), which inhibits SFRE-mediated transcription. Learn MoreStarting at: $70.00
