Multidrug Transporters
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Fumitremorgin C
Fumitremorgin is a chemosensitizing agent which selectively reverses BCRP-mediated multidrug resistance. Learn MoreStarting at: $170.00
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CP 100356 hydrochloride
CP 100356 hydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms) which inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). Learn MoreStarting at: $155.00
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Elacridar hydrochloride
P-glycoprotein (P-gp/ABCG1) inhibitor, which blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin and vincristine in CHRC5 cells. It also inhibits breast cancer resistance protein (BCRP/ABCG2). Learn MoreStarting at: $100.00
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XR 9051 HCl
XR 9051 HCl is a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) that inhibits the binding of cytotoxics to P-glycoprotein (EC50 = 134 nM). Learn MoreStarting at: $135.00
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Reversan
Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Learn MoreStarting at: $139.00