Matrix Metalloprotease
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Ro 32-3555
Ro 32-3555 is a potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively) which inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Learn MoreStarting at: $175.00
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ARP 100
ARP 100 is a selective inhibitor of MMP-2 (IC50 = 12 nM) with selectivity over MMP-9, MMP-3, MMP-1 and MMP-7. Learn MoreStarting at: $99.00
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WAY 170523
WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively). Learn MoreStarting at: $79.00
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GI 254023X
GI 254023X is a selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Learn MoreStarting at: $119.00
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Doxycycline hyclate
Doxycycline hyclate is a broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Learn MoreStarting at: $80.00
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UK 370106
UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Learn MoreStarting at: $155.00
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UK 356618
UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM), which displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively). Learn MoreStarting at: $189.00
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ONO 4817
ONO 4817 is a broad spectrum MMP inhibitor; Ki values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC50 = 1600 nM for MMP-1). It exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma. Learn MoreStarting at: $189.00
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CP 471474
CP 471474 is a broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Learn MoreStarting at: $95.00
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PD 166793
PD 166793 is a broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure. Learn MoreStarting at: $90.00
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ARP 101
ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1. Learn MoreStarting at: $115.00