Ligases
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L189
L189 is a DNA ligase I, III and IV inhibitor with IC50 values of 5, 9 and 5 μM respectively. Learn MoreStarting at: $119.00
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TAME hydrochloride
TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Learn MoreStarting at: $39.00
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PRT 4165
PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1), and inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Learn MoreStarting at: $65.00
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HLI 373
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3), which blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Learn MoreStarting at: $109.00
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NSC 66811
NSC 66811 is a potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Learn MoreStarting at: $119.00