JAK Kinase
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Cucurbitacin I
Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling, which inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Learn MoreStarting at: $169.00
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ZM 449829
Potent is a selective inhibitor of Janus tyrosine kinase 3 (JAK3), which binds competitively to the JAK3 ATP site. And inhibits STAT-5 phosphorylation and T-cell proliferation. Learn MoreStarting at: $89.00
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TCS 21311
TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM), which inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively). Learn MoreStarting at: $155.00
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1,2,3,4,5,6-Hexabromocyclohexane
1,2,3,4,5,6-Hexabromocyclohexane potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. Learn MoreStarting at: $75.00
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ZM 39923 hydrochloride
ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) with pIC50 values of 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Learn MoreStarting at: $119.00
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NSC 33994
NSC 33994 is a selective inhibitor of JAK2 with an IC50 value of 60 nM. Learn MoreStarting at: $139.00