GPR35
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ML 145
ML 145 is a selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists. Learn MoreStarting at: $130.00
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CID 2745687
CID 2745687 is a competitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM) which blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid. Learn MoreStarting at: $119.00
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Zaprinast
Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Learn MoreStarting at: $65.00
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YE 120
YE 120 is a GPR35 agonist (EC50 = 32 nM in DMR assays), which displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). Learn MoreStarting at: $139.00
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TC-G 1001
TC-G 1001 is a GPR35 agonist (pEC50 values are 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays respectively), which displays 1000-fold greater potency at human GPR35 receptors relative to mouse and rat GPR35 orthologs in an IP1 accumulation assay. Learn MoreStarting at: $139.00
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Pamoic acid disodium salt
Pamoic acid disodium salt is a GPR35 agonist that induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 and 65 nM respectively. Learn MoreStarting at: $60.00