Glutamate (EAAT) Transporters
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Chicago Sky Blue 6B
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM) and MIF proinflammatory activity. Learn MoreStarting at: $49.00
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cis-ACBD
cis-ACBD is a potent, competitive and selective inhibitor of glutamate uptake. Learn MoreStarting at: $99.00
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L-(-)-threo-3-Hydroxyaspartic acid
L-(-)-threo-3-Hydroxyaspartic acid is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Learn MoreStarting at: $149.00
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L-trans-2,4-PDC
L-trans-2,4-PDC is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Learn MoreStarting at: $115.00
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(±)-threo-3-Methylglutamic acid
(±)-threo-3-Methylglutamic acid is a potent blocker of glutamate transport. Learn MoreStarting at: $89.00
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Dihydrokainic acid
Dihydrokainic acid is a EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake. Learn MoreStarting at: $49.00
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MPDC
MM 77 dihydrochloride is a highly potent and fairly selective 5-HT1A ligand, which may be a full antagonist at postsynaptic receptors. Learn MoreStarting at: $135.00
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TFB-TBOA
TFB-TBOA is a high affinity, selective blocker of glial glutamate transporters EAAT1 and EAAT2 (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively), which displays no activity on a wide range of neurotransmitter receptors and transporters. Learn MoreStarting at: $89.00
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Evans Blue tetrasodium salt
Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). Learn MoreStarting at: $65.00
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(±)-HIP-B
(±)-HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Learn MoreStarting at: $139.00
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(±)-HIP-A
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Learn MoreStarting at: $139.00
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DL-TBOA
DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 70, 6, and 6 μM for EAAT1, EAAT2 and EAAT3 respectively), which also inhibits EAAT4 and EAAT5 (Ki values are 4.4 and 3.2 μM respectively). Learn MoreStarting at: $140.00
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7-Chlorokynurenic acid
7-Chlorokynurenic acid is a NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Learn MoreStarting at: $60.00
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7-Chlorokynurenic acid sodium salt
7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid, an NMDA receptor antagonist acting at the glycine site. Learn MoreStarting at: $65.00
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L-CCG-lll
L-CCG-lll is a potent and competitive inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate. Learn MoreStarting at: $265.00
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Ceftriaxone disodium salt
Ceftriaxone disodium salt is β-lactam antibiotic, which increased activity of the EAAT2 glutamate transporter and displays neuroprotective activity in vivo via upregulation. Learn MoreStarting at: $49.00
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WAY 213613
WAY 213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3. Learn MoreStarting at: $139.00