Chloride Channels
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NPPB
NPPB is an inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist. Learn MoreStarting at: $105.00
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CaCCinh-A01
Calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM), which inhibits CaCC currents in human bronchial and intestinal cells. Learn MoreStarting at: $99.00
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Eact
Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Ca2+-independent, which displays no effect on CFTR Cl- or ENaC Na+ conductance, and stimulates submucosal gland secretion in human bronchi. Learn MoreStarting at: $125.00
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T16Ainh-A01
T16Ainh-A01 is an inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Learn MoreStarting at: $119.00
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DCEBIO
DCEBIO stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. Learn MoreStarting at: $99.00
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9-AC
9-AC is a Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI. Learn MoreStarting at: $65.00
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KM 11060
KM 11060 increases the amount of functional CFTR at the plasma membrane (~75%). Learn MoreStarting at: $105.00
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DCPIB
DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) that reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Learn MoreStarting at: $109.00
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PG 01
PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. Learn MoreStarting at: $115.00