Chemokine Receptors
-
IT1t dihydrochloride
IT1t dihydrochloride is a potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays), which blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment). Learn MoreStarting at: $120.00
-
ZK 756326
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist with IC50 values of 1.8 and 2.6 μM for human and mouse receptors respectively. Learn MoreStarting at: $105.00
-
C 021 dihydrochloride
C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist with IC50 values of 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively. Learn MoreStarting at: $149.00
-
SB 297006
SB 297006, a potent and selective CCR3 antagonist, displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 and nhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR. Learn MoreStarting at: $129.00
-
BMS CCR2 22
BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM), which displays potent functional antagonism, IC50 values are 1 and 18 nM for antagonism of calcium flux and chemotaxis respectively. Learn MoreStarting at: $79.00
-
J 113863
J 113863 is a potent chemokine receptor 1 (CCR1) antagonist (IC50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively), which displays high selectivity for human but not mouse CCR3 receptors (IC50 values are 0.58 and 460 nM respectively). Learn MoreStarting at: $79.00
-
UCB 35625
UCB 35625 is a potent chemokine CCR1 and CCR3 receptor antagonist, which inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50 values are 9.57 and 93.8 nM respectively). Learn MoreStarting at: $89.00
-
RS 504393
Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively), which inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys. Learn MoreStarting at: $139.00
-
RS 102895 hydrochloride
RS 102895 hydrochloride is a CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively) which blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Learn MoreStarting at: $99.00
-
SB 328437
SB 328437 is a potent and selective CCR3 antagonist (IC50 = 4 nM) which displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Learn MoreStarting at: $119.00
-
Teijin compound 1
Teijin compound 1 is a potent chemokine CCR2b receptor antagonist (IC50 = 180 nM), which potently inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM). Learn MoreStarting at: $140.00
-
BX 513 hydrochloride
BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively), which inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Learn MoreStarting at: $140.00
-
PSB 1114
PSB 1114 is a potent, selective P2Y2 agonist (EC50 = 0.134 μM), which displays >60-fold selectivity versus P2Y4 and P2Y6 receptors. Learn MoreStarting at: $215.00