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Search results for 'inhibit'
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SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
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(S)-Methylisothiourea sulfate
(S)-Methylisothiourea sulfate is a highly selective, potent competitive inhibitor of iNOS. Learn MoreStarting at: $79.00
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DPPI 1c hydrochloride
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) that increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge. Learn MoreStarting at: $85.00
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TC-E 5001
TC-E 5001 is a dual tankyrase (TNKS) inhibitor that inhibits wnt signaling and stabilizes Axin2 levels. Learn MoreStarting at: $99.00
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C 021 dihydrochloride
C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist with IC50 values of 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively. Learn MoreStarting at: $149.00
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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn MoreStarting at: $189.00
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5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) that displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma). Learn MoreStarting at: $119.00
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6-Iodonordihydrocapsaicin
6-Iodonordihydrocapsaicin is a potent competitive vanilloid TRPV1 (VR1) receptor antagonist that inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro. Learn MoreStarting at: $115.00
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Vialinin A
Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity. Learn MoreStarting at: $65.00
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K-252c
K-252c is an inhibitor of protein kinase C that exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). Learn MoreStarting at: $99.00
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PF 915275
PF 915275 is a potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor that inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. Learn MoreStarting at: $115.00
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AM 114
AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome that inhibits cell growth in human colon cancer HCT116 p53+/+ cells. Learn MoreStarting at: $99.00
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Mirtazapine
Mirtazapine is an antidepressant agent that enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters. Learn MoreStarting at: $85.00
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(R)-(-)-Rolipram
(R)-(-)-Rolipram is an enantiomer of the PDE4 inhibitor rolipram that is 2-10-fold more potent than the S-(+) enantiomer. Learn MoreStarting at: $139.00
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OGT 2115
OGT 2115 is a heparanase inhibitor that displays no major inhibition of human cytochrome P450 isoenzymes. Learn MoreStarting at: $59.00
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SecinH3
SecinH3 is a sec7-specific GEF inhibitor that inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation. Learn MoreStarting at: $169.00
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PF 514273
PF 514273 is a potent and selective CB1 receptor antagonist that inhibits food intake in vivo following oral administration. Learn MoreStarting at: $139.00
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ARP 101
ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1. Learn MoreStarting at: $115.00
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NCH 51
NCH 51 is a histone deacetylase (HDAC) inhibitor that inhibits growth of various cancer cells in vitro. Learn MoreStarting at: $115.00
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HKI 357
HKI 357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR that suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Learn MoreStarting at: $189.00
