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Search results for 'inhibit'
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TCS JNK 6o
TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor that inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro. Learn MoreStarting at: $149.00
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VU 0240551
VU 0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 that also inhibits hERG and L-type Ca2+ channels. Learn MoreStarting at: $115.00
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(-)-Xestospongin C
(-)-Xestospongin C is a highly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release with an IC50 value of 358 nM. Learn MoreStarting at: $149.00
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W-13 hydrochloride
W-13 hydrochloride is a calmodulin antagonist that inhibits calmodulin activated PDE activity with an IC50 of 68 μM. Learn MoreStarting at: $99.00
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CCG 50014
CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein that exhibits >20-fold selectivity for RGS4 over other RGS proteins. Learn MoreStarting at: $125.00
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HC 067047
HC 067047 is a potent and selective TRPV4 antagonist that reversibly inhibits currents through mouse, human and rat TRPV4 orthologs. Learn MoreStarting at: $139.00
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MDL 28170
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B that rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Learn MoreStarting at: $65.00
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G-1
G-1 is a potent and selective GPR30 receptor agonist that increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants with IC50 values of 0.7 and 1.6 nM respectively in vitro. Learn MoreStarting at: $139.00
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DuP 697
DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 with IC50 values of10 and 800 nM for COX-2 and COX-1 respectively. Learn MoreStarting at: $115.00
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KU 0060648
KU 0060648 is a dual, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and PI 3-K. Learn MoreStarting at: $195.00
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HDS 029
HDS 029 is a potent inhibitor of the ErbB receptor family that inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells. Learn MoreStarting at: $85.00
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PPY A
PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases that inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene. Learn MoreStarting at: $169.00
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MEDICA 16
MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist that reduces intracellular triacylglycerol levels in muscle and inhibits lipogenesis and increases insulin sensitivity in rodents in vivo. Learn MoreStarting at: $115.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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SC 66
SC 66 is an allosteric inhibitor of Akt that interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Learn MoreStarting at: $75.00
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Leptomycin B
Leptomycin B, an antifungal antibiotic, is an inhibitor of the nuclear export of proteins that inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Learn MoreStarting at: $239.00
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JNJ 10191584 maleate
JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist that inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Learn MoreStarting at: $99.00
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Indatraline hydrochloride
Indatraline hydrochloride is a potent monoamine uptake inhibitor that inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET). Learn MoreStarting at: $95.00
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WAY 213613
WAY 213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3. Learn MoreStarting at: $139.00
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LY 2365109 hydrochloride
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor that induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Learn MoreStarting at: $149.00
