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SANT-2
SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM), which displays allosteric binding characteristics similar to SANT-1. Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively). Learn MoreStarting at: $139.00
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BPIPP
BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor, which downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). It also inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo. Learn MoreStarting at: $145.00
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GW 0742
GW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Learn MoreStarting at: $129.00
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Bupropion hydrochloride
Bupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively), which also inhibits neuronal nicotinic acetylcholine receptors. Learn MoreStarting at: $99.00
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PD 118057
PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, which displays no major effect on INa, ICa/L, IK1 and IKs currents. Learn MoreStarting at: $119.00
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VU 590 dihydrochloride
VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM), which also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Learn MoreStarting at: $85.00
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Reversan
Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Learn MoreStarting at: $139.00
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LU AA33810
LU AA33810 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro) which displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Learn MoreStarting at: $109.00
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Oleamide
Oleamide endogenous sleep-inducing lipid, which acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Learn MoreStarting at: $59.00
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RS 102895 hydrochloride
RS 102895 hydrochloride is a CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively) which blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Learn MoreStarting at: $99.00
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IBMX
IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively) which suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Learn MoreStarting at: $59.00
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JTE 907
JTE 907 is a highly selective cannabinoid CB2 receptor inverse agonist, which binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Learn MoreStarting at: $139.00
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LE 300
LE 300 is a potent and selective dopamine D1 receptor antagonist (Ki values are 0.08 - 1.9 nM and 6 - 45 nM for D1 and D2 receptors respectively), which also displays moderate affinity for the 5-HT2A receptor (Ki = 20 nM). Active in vivo. Learn MoreStarting at: $139.00
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MRS 1754
MRS 1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively). Learn MoreStarting at: $139.00
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MRS 1706
MRS 1706 is a potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively). Learn MoreStarting at: $119.00
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KF 38789
KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Learn MoreStarting at: $135.00
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RWJ 52353
RWJ 52353 is an agonist of the α2D adrenergic receptor (Ki values are 1.5, 254, 443 and 621 nM for α2D, α2A, α1 and α2B adrenergic receptors respectively). Learn MoreStarting at: $140.00
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Ambroxol hydrochloride
Ambroxol hydrochloride is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties, which inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Learn MoreStarting at: $69.00
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UK 370106
UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Learn MoreStarting at: $155.00
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(±)-HIP-B
(±)-HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Learn MoreStarting at: $139.00
