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Search results for 'Glutamate'
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LY 487379 hydrochloride
LY 487379 hydrochloride is a positive allosteric modulator selective for mGlu2 receptors, which potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 μM for mGlu2 and mGlu3 receptors respectively). Learn MoreStarting at: $110.00
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VU 0285683
VU 0285683 is a negative allosteric modulator of mGlu5 receptors, which displays high affinity for the MPEP binding site and acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Learn MoreStarting at: $125.00
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(RS)-3-Hydroxyphenylglycine
(RS)-3-Hydroxyphenylglycine is an agonist at PI-linked metabotropic glutamate receptors. Separate isomer (S)-3-Hydroxyphenylglycine also available. Learn MoreStarting at: $99.00
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Evans Blue tetrasodium salt
Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). Learn MoreStarting at: $65.00
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Ro 01-6128
Ro 01-6128 is a positive allosteric modulator of mGlu1 receptors, which potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a). Learn MoreStarting at: $85.00
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YM 202074
High affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist which binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Learn MoreStarting at: $139.00
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Ro 67-7476
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors which potentiates glutamate-induced calcium release (EC50 = 60.1 nM at rat mGluR1a). Learn MoreStarting at: $129.00
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MNI-caged-L-glutamate
MNI-caged-L-glutamate is a MNI-caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation). Learn MoreStarting at: $139.00
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Licarbazepine
Licarbazepine is an active metabolite of oxcarbazepine which produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Learn MoreStarting at: $85.00
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L-AP4
L-AP4 is a selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Learn MoreStarting at: $60.00
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(±)-HIP-B
(±)-HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Learn MoreStarting at: $139.00
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(±)-HIP-A
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Learn MoreStarting at: $139.00
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DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
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(RS)-3,5-DHPG
(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Learn MoreStarting at: $49.00
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7-Chlorokynurenic acid
7-Chlorokynurenic acid is a NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Learn MoreStarting at: $60.00
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PMPA (NAALADase inhibitor)
PMPA (NAALADase inhibitor) is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Learn MoreStarting at: $90.00
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DFB
DFB is a novel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Learn MoreStarting at: $70.00
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(S)-MCPG
(S)-MCPG is a active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist. Learn MoreStarting at: $185.00
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CGP 55845 hydrochloride
CGP 55845 hydrochloride is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively). Learn MoreStarting at: $140.00
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(RS)-MCPG
(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist. Learn MoreStarting at: $95.00
