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Search results for 'inhibit'
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(E)-FeCP-oxindole
(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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L-651,582
L-651,582 is an orally active Ca2+ channel blocker which inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Learn MoreStarting at: $149.00
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BTZO 1
BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM), which activates antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Learn MoreStarting at: $95.00
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Decynium 22
Decynium 22 is an inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM). Learn MoreStarting at: $49.00
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(-)-5'-DMH-CBD
(-)-5'-DMH-CBD is an anandamide membrane transport inhibitor (IC50 = 14 μM) that is relatively metabolically stable, which displays some affinity for CB2 receptors but has only weak affinity for CB1 receptors and has no activity at VR1 receptors or FAAH. Learn MoreStarting at: $149.00
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AMN 082 dihydrochloride
AMN 082 dihydrochloride is the first selective mGlu7 agonist, which potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Learn MoreStarting at: $89.00
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(±)-McN 5652
(±)-McN 5652 is a potent, high affinity serotonin re-uptake inhibitor; selective in viv, and displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Learn MoreStarting at: $139.00
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SD 1008
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor, which inhibits activation of STAT3, JAK2 and Src. Learn MoreStarting at: $109.00
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PF 750
PF 750 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor that displays no activity at a range of other serine hydrolases. Learn MoreStarting at: $149.00
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SID 26681509
SID 26681509 is a potent and reversible human cathepsin L inhibitor with an IC50 value of 56 nM. Learn MoreStarting at: $149.00
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PF 04217903 mesylate
PF 04217903 mesylate is a highly selective, high affinity c-Met inhibitor that displays >1000-fold selectivity for c-Met over a panel of 208 kinases. Learn MoreStarting at: $189.00
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TCS HDAC6 20b
TCS HDAC6 20b is a selective inhibitor of histone deacetylase 6 (HDAC6) that inhibits HCT116 growth in combination with taxol. Learn MoreStarting at: $149.00
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WWL 70
WWL 70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 70 nM. Learn MoreStarting at: $75.00
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MNI 137
MNI 137 is a selective negative allosteric modulator of group II mGlu receptors with IC50 values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. Learn MoreStarting at: $139.00
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(R)-(+)-m-Nitrobiphenyline oxalate
(R)-(+)-m-Nitrobiphenyline oxalate is a α2C-adrenoceptor agonist that potently inhibits cAMP accumulation in CHO cells with an EC50 value of 38 nM. Learn MoreStarting at: $149.00
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JNJ 28871063 hydrochloride
JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor with IC50 values of 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively. Learn MoreStarting at: $139.00
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Anandamide
Anandamide is an endogenous cannabinoid and TRPV1 receptor agonist that also blocks TNF-α-induced NF-κB activation via direct inhibition of IKK. Learn MoreStarting at: $59.00
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MJ 15
MJ 15 is a potent and selective CB1 receptor antagonist that inhibits food intake and increases in body weight in diet-induced obese rats and mice. Learn MoreStarting at: $139.00
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PHA 767491 hydrochloride
PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor with IC50 valuesof 10 and 34 nM respectively. Learn MoreStarting at: $99.00
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PI 828
PI 828 is a PI 3-Kinase inhibitor with IC50 values of 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively. Learn MoreStarting at: $69.00
