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Search results for 'WIN'
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Nomifensine
Nomifensine is a potent inhibitor of noradrenalin and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain), which increases central dopamine levels in rats following systemic administration. Learn MoreStarting at: $79.00
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TCS 46b
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively), whih potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. Learn MoreStarting at: $109.00
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PPT
PPT is a potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM) which displays 410-fold selectivity for ERα over ER&beta, and prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. Learn MoreStarting at: $119.00
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Bay 36-7620
Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity, which exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration. Learn MoreStarting at: $155.00
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(±)-Vesamicol hydrochloride
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM), which centrally active following systemic administration in vivo. Learn MoreStarting at: $69.00
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AM 281
AM 281 is a potent, selective CB1 cannabinoid receptor antagonist/inverse agonist (Ki values are 12 and 4200 nM for CB1 and CB2 receptors respectively), which increases locomotor activity following systemic administration in vivo. Learn MoreStarting at: $140.00
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(S)-3,4-DCPG
(S)-3,4-DCPG is a potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7, which increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Learn MoreStarting at: $140.00
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SNC 162
SNC 162 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM) which displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo. Learn MoreStarting at: $160.00
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SM-21 maleate
SM-21 maleate is a potent and selective σ2 antagonist with central effects following systemic administration. Learn MoreStarting at: $95.00
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YM 90K hydrochloride
YM 90K hydrochloride is a selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. Learn MoreStarting at: $150.00
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BMS 182874 hydrochloride
BMS 182874 hydrochloride is a potent, selective and competitive non-peptide endothelin ETA receptor antagonist (Ki = 48 nM) which displays > 1000-fold selectivity over ETB receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo and inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro. Learn MoreStarting at: $140.00
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WIN 64338 hydrochloride
L-NIL hydrochloride is the first potent, non-peptide, competitive bradykinin B2 receptor antagonist. Learn MoreStarting at: $110.00
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WIN 18446
WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM) which inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. Learn MoreStarting at: $80.00
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A 77636 hydrochloride
A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively), which displays anti-Parkinsonian activity following oral administration in vivo. Learn MoreStarting at: $140.00
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FK 888
FK 888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors which inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration. Learn MoreStarting at: $195.00
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WIN 55,212-3 mesylate
WIN 55,212-3 mesylate is a novel, low potency CB2 receptor silent antagonist and CB1 receptor partial inverse agonist, which competitively antagonizes effects of CP 55,940 (pA2 = 6.1) and SR 144528 (pEC50 = 5.3) at CB2 receptors and acts as a partial inverse agonist at CB1 receptors (pIC50 = 5.5). Learn MoreStarting at: $90.00
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Y-27152
Y-27152 is a prodrug of the Kir6 (KATP) channel opener Y-26763, which produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals. Learn MoreStarting at: $130.00
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BRL 44408 maleate
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Learn MoreStarting at: $100.00
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Naltrindole hydrochloride
Naltrindole hydrochloride is a highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors. Learn MoreStarting at: $95.00
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BMY 14802 hydrochloride
BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems. Learn MoreStarting at: $85.00
