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Search results for 'Glutamate'
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Hexamethonium bromide
Hexamethonium bromide is a Nicotinic receptor (nAChR) blocker at autonomic ganglia that induces changes in neuronal activity similar to the influences of glutamate in vitro. Learn MoreStarting at: $20.00
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(S)-3-Carboxy-4-hydroxyphenylglycine
(S)-3-Carboxy-4-hydroxyphenylglycine is a mixed group I metabotropic glutamate receptor antagonist and group II mGlu agonist. Learn MoreStarting at: $269.00
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L-Quisqualic acid
L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Learn MoreStarting at: $65.00
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Dihydrokainic acid
Dihydrokainic acid is a EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake. Learn MoreStarting at: $49.00
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3-MATIDA
3-MATIDA is a potent metabotropic glutamate mGlu1 receptor antagonist with IC50 = 6.3 μM at rat mGlu1a. Learn MoreStarting at: $140.00
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E4CPG
(RS)-APICA is a rigidified analog of MPPG; selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Learn MoreStarting at: $95.00
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CHPG
E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG. Learn MoreStarting at: $80.00
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SC 236
CHPG is a selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Learn MoreStarting at: $110.00
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MPPG
MTPG is a group II/group III metabotropic glutamate receptor antagonist, showing selectivity for group II in electrophysiological studies. Learn MoreStarting at: $135.00
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RS 67506 hydrochloride
(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Learn MoreStarting at: $90.00
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Tacrine hydrochloride
AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Learn MoreStarting at: $60.00
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BW 723C86 hydrochloride
DMP 543 is a K+ channel blocker and acetylcholine release stimulator, which potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Learn MoreStarting at: $95.00
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PNU 22394 hydrochloride
MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn MoreStarting at: $95.00
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L-755,507
L-BMAA hydrochloride is a neurotoxic glutamate agonist originally isolated from Cycas circinalis. Learn MoreStarting at: $115.00
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TFB-TBOA
TFB-TBOA is a high affinity, selective blocker of glial glutamate transporters EAAT1 and EAAT2 (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively), which displays no activity on a wide range of neurotransmitter receptors and transporters. Learn MoreStarting at: $89.00
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JNJ 16259685
JNJ 16259685 is a sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM), which inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. Learn MoreStarting at: $169.00
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O-Phospho-L-serine
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4, which inhibits proliferation and enhances neuronal differentiation in progenitor cells. Learn MoreStarting at: $59.00
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NFPS
NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity on GlyT2 or the transport of proline, GABA or glutamate (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Learn MoreStarting at: $139.00
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DMeOB
DMeOB is a negative allosteric modulator of the metabotropic glutamate receptor mGlu5 which displays reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM). Learn MoreStarting at: $79.00
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7,8-Dihydroxyflavone
7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). It inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Learn MoreStarting at: $119.00
